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Title: Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
Authors: Pang, Jeremy Kah Sheng
Ho, Beatrice Xuan
Chan, Woon-Khiong 
Soh, Boon-Seng 
Keywords: biomaterials
cardiovascular disease modelling
drug screening
embryonic development
organoid systems
stem cell
Issue Date: 2-Dec-2021
Publisher: Frontiers Media S.A.
Citation: Pang, Jeremy Kah Sheng, Ho, Beatrice Xuan, Chan, Woon-Khiong, Soh, Boon-Seng (2021-12-02). Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids. Frontiers in Cell and Developmental Biology 9 : 788955. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases. Copyright © 2021 Pang, Ho, Chan and Soh.
Source Title: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.788955
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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