Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2021.02.047
Title: AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury
Authors: Marino, Alice
Hausenloy, Derek J. 
Andreadou, Ioanna
Horman, Sandrine
Bertrand, Luc
Beauloye, Christophe
Keywords: AMPK
Cardiac hypertrophy
Heart failure
HFpEF
HFrEF
Ischemia
Ischemia/reperfusion injury
Nox
Reperfusion
ROS
Issue Date: 1-Apr-2021
Publisher: Elsevier Inc.
Citation: Marino, Alice, Hausenloy, Derek J., Andreadou, Ioanna, Horman, Sandrine, Bertrand, Luc, Beauloye, Christophe (2021-04-01). AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury. Free Radical Biology and Medicine 166 : 238-254. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2021.02.047
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Heart failure is one of the leading causes of death and disability worldwide. Left ventricle remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of cardiac function and predispose to the onset of heart failure. Adenosine monophosphate-activated protein kinase (AMPK) is the universally recognized energy sensor which responds to low ATP levels and restores cellular metabolism. AMPK activation controls numerous cellular processes and, in the heart, it plays a pivotal role in preventing onset and progression of disease. Excessive reactive oxygen species (ROS) generation, known as oxidative stress, can activate AMPK, conferring an additional role of AMPK as a redox-sensor. In this review, we discuss recent insights into the crosstalk between ROS and AMPK. We describe the molecular mechanisms by which ROS activate AMPK and how AMPK signaling can further prevent heart failure progression. Ultimately, we review the potential therapeutic approaches to target AMPK for the treatment of cardiovascular disease and prevention of heart failure. © 2021 The Author(s)
Source Title: Free Radical Biology and Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/232236
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2021.02.047
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1016_j_freeradbiomed_2021_02_047.pdf3.54 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

23
checked on Nov 25, 2022

Page view(s)

10
checked on Dec 1, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons