Please use this identifier to cite or link to this item: https://doi.org/10.1111/adb.12980
Title: Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: A cross-sectional study
Authors: Orban, Csaba 
McGonigle, John
Flechais, Remy S. A.
Paterson, Louise M.
Elliott, Rebecca
Erritzoe, David
Ersche, Karen D.
Murphy, Anna
Nestor, Liam J.
Passetti, Filippo
Reed, Laurence J.
Ribeiro, Andre S.
Smith, Dana G.
Suckling, John
Taylor, Eleanor M.
Waldman, Adam D.
Wing, Victoria C.
Deakin, J. F. William
Robbins, Trevor W.
Nutt, David J.
Lingford-Hughes, Anne R.
Nutt, David J.
Lingford-Hughes, Anne R.
Paterson, Louise M.
McGonigle, John
Flechais, Remy S. A.
Orban, Csaba 
Deakin, B.
Elliott, Rebecca
Murphy, Anna
Taylor, Eleanor M.
Robbins, Trevor W.
Ersche, Karen D.
Suckling, John
Smith, Dana G.
Reed, Laurence J.
Passetti, Filippo
Faravelli, L.
Erritzoe, David
Mick, I.
Kalk, N.
Waldman, Adam D.
Nestor, Liam J.
Kuchibatla, S.
Boyapati, V.
Metastasio, A.
Faluyi, Y.
Fernandez-Egea, E.
Abbott, S.
Sahakian, B.
Voon, V.
Rabiner, I.
ICCAM Platform.
Keywords: alcohol
amygdala
fMRI
Issue Date: 20-Nov-2020
Publisher: John Wiley and Sons Inc
Citation: Orban, Csaba, McGonigle, John, Flechais, Remy S. A., Paterson, Louise M., Elliott, Rebecca, Erritzoe, David, Ersche, Karen D., Murphy, Anna, Nestor, Liam J., Passetti, Filippo, Reed, Laurence J., Ribeiro, Andre S., Smith, Dana G., Suckling, John, Taylor, Eleanor M., Waldman, Adam D., Wing, Victoria C., Deakin, J. F. William, Robbins, Trevor W., Nutt, David J., Lingford-Hughes, Anne R., Nutt, David J., Lingford-Hughes, Anne R., Paterson, Louise M., McGonigle, John, Flechais, Remy S. A., Orban, Csaba, Deakin, B., Elliott, Rebecca, Murphy, Anna, Taylor, Eleanor M., Robbins, Trevor W., Ersche, Karen D., Suckling, John, Smith, Dana G., Reed, Laurence J., Passetti, Filippo, Faravelli, L., Erritzoe, David, Mick, I., Kalk, N., Waldman, Adam D., Nestor, Liam J., Kuchibatla, S., Boyapati, V., Metastasio, A., Faluyi, Y., Fernandez-Egea, E., Abbott, S., Sahakian, B., Voon, V., Rabiner, I., ICCAM Platform. (2020-11-20). Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: A cross-sectional study. Addiction Biology 26 (4) : e12980. ScholarBank@NUS Repository. https://doi.org/10.1111/adb.12980
Rights: Attribution 4.0 International
Abstract: Animal models have shown that chronic alcohol exposure is associated with persistent neuroadaptations in amygdala synaptic function, whereas human studies have consistently reported amygdala grey-matter volume (GMV) reductions in alcohol dependent patients (ADP). We hypothesised that chronic alcohol use associated with neuroadaptations may entail a reconfiguration of the amygdala's functional interactions and that these mechanisms may be affected by structural atrophy. We compared amygdala resting state functional connectivity (RSFC) using a whole brain seed-based approach and amygdala GMV in abstinent ADP (n = 20) and healthy controls (HC; n = 39), balanced for age, gender and levels of head motion. The potential moderating influence of age, cumulative alcohol exposure, abstinence length and head motion was further examined in the two groups separately using correlational analyses. We found increased amygdala RSFC with substantia nigra/ventral tegmental area (SN/VTA) in ADP compared with HC. As expected, amygdala GMV was lower in ADP. Multiple regression analyses of the ADP group showed that amygdala-SN/VTA RSFC increases were primarily associated with cumulative alcohol exposure rather than age, whereas amygdala GMV reductions were primarily associated with age rather than cumulative alcohol exposure. The same association between age and amygdala GMV was not observed amongst HC. Importantly, amygdala GMV and amygdala-SN/VTA RSFC were uncorrelated in ADP, and neither measure was correlated with abstinence length. These results suggest that chronic alcohol exposure is associated with persistent elevations in amygdala-SN/VTA RSFC and accelerated age-related grey-matter atrophy through potentially distinct mechanisms. © 2020 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction
Source Title: Addiction Biology
URI: https://scholarbank.nus.edu.sg/handle/10635/232226
ISSN: 1355-6215
DOI: 10.1111/adb.12980
Rights: Attribution 4.0 International
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