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Title: The pathogenesis and diagnosis of sepsis post burn injury
Authors: Zhang, Pengju
Zou, Bingwen
Liou, Yih-Cherng 
Huang, Canhua
Keywords: Biomaker
Immune dysregulation
Multiple organ dysfunction syndrome
Septic shock
Issue Date: 1-Jan-2021
Publisher: Oxford University Press
Citation: Zhang, Pengju, Zou, Bingwen, Liou, Yih-Cherng, Huang, Canhua (2021-01-01). The pathogenesis and diagnosis of sepsis post burn injury. Burns and Trauma 9 : tkaa047. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Burn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality. Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care, nutritional and fluid resuscitation and improved infection control practices, there are still large numbers of patients at a high risk of death. One of the most common complications of burn is sepsis, which is defined as "severe organ dysfunction attributed to host's disordered response to infection"and is the primary cause of death in burn patients. Indeed, burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome, such as a hypovolaemic state, immune and inflammatory responses and metabolic changes. Therefore, clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock. In this review, we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis. Moreover, the clinical and promising biomarkers of burn sepsis will also be summarized. © 2021 The Author(s) 2021. Published by Oxford University Press.
Source Title: Burns and Trauma
ISSN: 2321-3876
DOI: 10.1093/burnst/tkaa047
Rights: Attribution 4.0 International
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