Please use this identifier to cite or link to this item: https://doi.org/10.1093/burnst/tkaa047
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dc.titleThe pathogenesis and diagnosis of sepsis post burn injury
dc.contributor.authorZhang, Pengju
dc.contributor.authorZou, Bingwen
dc.contributor.authorLiou, Yih-Cherng
dc.contributor.authorHuang, Canhua
dc.date.accessioned2022-10-11T08:04:41Z
dc.date.available2022-10-11T08:04:41Z
dc.date.issued2021-01-01
dc.identifier.citationZhang, Pengju, Zou, Bingwen, Liou, Yih-Cherng, Huang, Canhua (2021-01-01). The pathogenesis and diagnosis of sepsis post burn injury. Burns and Trauma 9 : tkaa047. ScholarBank@NUS Repository. https://doi.org/10.1093/burnst/tkaa047
dc.identifier.issn2321-3876
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232161
dc.description.abstractBurn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality. Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care, nutritional and fluid resuscitation and improved infection control practices, there are still large numbers of patients at a high risk of death. One of the most common complications of burn is sepsis, which is defined as "severe organ dysfunction attributed to host's disordered response to infection"and is the primary cause of death in burn patients. Indeed, burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome, such as a hypovolaemic state, immune and inflammatory responses and metabolic changes. Therefore, clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock. In this review, we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis. Moreover, the clinical and promising biomarkers of burn sepsis will also be summarized. © 2021 The Author(s) 2021. Published by Oxford University Press.
dc.publisherOxford University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectBiomaker
dc.subjectBurn
dc.subjectHypermetabolism
dc.subjectImmune dysregulation
dc.subjectInfection
dc.subjectInflammation
dc.subjectMultiple organ dysfunction syndrome
dc.subjectSepsis
dc.subjectSeptic shock
dc.subjectTrauma
dc.typeReview
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1093/burnst/tkaa047
dc.description.sourcetitleBurns and Trauma
dc.description.volume9
dc.description.pagetkaa047
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