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Title: Recommendations for good practice in ms-based lipidomics
Authors: Köfeler, H.C.
Ahrends, Robert
Baker, Erin S.
Ekroos, Kim
Han, Xianlin
Hoffmann, Nils
Holcapek, Michal
Wenk, Markus R. 
Liebisch, Gerhard
Keywords: Chromatography
Ion mobility spectrometry
Lipid identification
Issue Date: 1-Jan-2021
Publisher: American Society for Biochemistry and Molecular Biology Inc.
Citation: Köfeler, H.C., Ahrends, Robert, Baker, Erin S., Ekroos, Kim, Han, Xianlin, Hoffmann, Nils, Holcapek, Michal, Wenk, Markus R., Liebisch, Gerhard (2021-01-01). Recommendations for good practice in ms-based lipidomics. Journal of Lipid Research 62 : 100138. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: In the last 2 decades, lipidomics has become one of the fastest expanding scientific disciplines in biomedical research. With an increasing number of new research groups to the field, it is even more important to design guidelines for assuring high standards of data quality. The Lipidomics Standards Initiative is a community-based endeavor for the coordination of development of these best practice guidelines in lipidomics and is embedded within the International Lipidomics Society. It is the intention of this review to highlight the most quality-relevant aspects of the lipidomics workflow, including preanalytics, sample preparation, MS, and lipid species identification and quantitation. Furthermore, this review just does not only highlights examples of best practice but also sheds light on strengths, drawbacks, and pitfalls in the lipidomic analysis workflow. While this review is neither designed to be a step-by-step protocol by itself nor dedicated to a specific application of lipidomics, it should nevertheless provide the interested reader with links and original publications to obtain a comprehensive overview concerning the state-of-the-art practices in the field. © 2021 American Society for Biochemistry and Molecular Biology Inc.. All rights reserved.
Source Title: Journal of Lipid Research
ISSN: 0022-2275
DOI: 10.1016/j.jlr.2021.100138
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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