Please use this identifier to cite or link to this item: https://doi.org/10.3390/nano11020497
Title: Synthesis and characterization of chitosan-based nanodelivery systems to enhance the anticancer effect of sorafenib drug in hepatocellular carcinoma and colorectal adenocarcinoma cells
Authors: Ruman, Umme
Buskaran, Kalaivani
Pastorin, Giorgia 
Masarudin, Mas Jaffri
Fakurazi, Sharida
Hussein, Mohd Zobir
Keywords: Cancer
Cell lines
Chitosan-nanoparticles
Drug-delivery
Folic acid
HDFa
HepG2
HT29
Sorafenib
Therapeutic
Issue Date: 16-Feb-2021
Publisher: MDPI AG
Citation: Ruman, Umme, Buskaran, Kalaivani, Pastorin, Giorgia, Masarudin, Mas Jaffri, Fakurazi, Sharida, Hussein, Mohd Zobir (2021-02-16). Synthesis and characterization of chitosan-based nanodelivery systems to enhance the anticancer effect of sorafenib drug in hepatocellular carcinoma and colorectal adenocarcinoma cells. Nanomaterials 11 (2) : Jan-28. ScholarBank@NUS Repository. https://doi.org/10.3390/nano11020497
Rights: Attribution 4.0 International
Abstract: The formation of two nanodelivery systems, Sorafenib (SF)-loaded chitosan (SF-CS) and their folate-coated (SF-CS-FA) nanoparticles (NPs), were developed to enhance SF drug delivery on human Hepatocellular Carcinoma (HepG2) and Colorectal Adenocarcinoma (HT29) cell lines. The ionic gelation method was adopted to synthesize the NPs. The characterizations were performed by DLS, FESEM, TEM, XRD, TGA, FTIR, and UV-visible spectroscopy. It was found that 83.7 ± 2.4% and 87.9 ± 1.1% of encapsulation efficiency; 18.2 ± 1.3% and 19.9 ± 1.4% of loading content; 76.3 ± 13.7 nm and 81.6 ± 12.9 nm of hydrodynamic size; 60–80 nm and 70–100 nm of TEM; and FESEM sizes of near-spherical shape were observed, respectively, for SF-CS and SF-CS-FA nanoparticles. The SF showed excellent release from the nanoparticles under pH 4.8 PBS solution, indicating a good delivery system for tumor cells. The cytotoxicity study revealed their better anticancer action towards HepG2 and HT29 cell lines compared to the free sorafenib. Moreover, both NPs systems showed negligible toxicity to normal Human Dermal Fibroblast adult cells (HDFa). This is towards an enhanced anticancer drug delivery system with sustained-release properties for better cancer management. © 2021 by the author. Licensee MDPI, Basel, Switzerland.
Source Title: Nanomaterials
URI: https://scholarbank.nus.edu.sg/handle/10635/232145
ISSN: 2079-4991
DOI: 10.3390/nano11020497
Rights: Attribution 4.0 International
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