Please use this identifier to cite or link to this item:
https://doi.org/10.1172/jci.insight.147190
Title: | Hypoxia and viral infectious diseases | Authors: | Huang, Richard Huestis, Melissa Gan, Esther Shuyi Ooi, Eng Eong Ohh, Michael |
Issue Date: | 8-Apr-2021 | Publisher: | American Society for Clinical Investigation | Citation: | Huang, Richard, Huestis, Melissa, Gan, Esther Shuyi, Ooi, Eng Eong, Ohh, Michael (2021-04-08). Hypoxia and viral infectious diseases. JCI Insight 6 (7) : e147190. ScholarBank@NUS Repository. https://doi.org/10.1172/jci.insight.147190 | Rights: | Attribution 4.0 International | Abstract: | Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis. © 2021, Huang et al. | Source Title: | JCI Insight | URI: | https://scholarbank.nus.edu.sg/handle/10635/232101 | ISSN: | 2379-3708 | DOI: | 10.1172/jci.insight.147190 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1172_jci_insight_147190.pdf | 2.12 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License