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Title: Hypoxia and viral infectious diseases
Authors: Huang, Richard
Huestis, Melissa
Gan, Esther Shuyi 
Ooi, Eng Eong 
Ohh, Michael
Issue Date: 8-Apr-2021
Publisher: American Society for Clinical Investigation
Citation: Huang, Richard, Huestis, Melissa, Gan, Esther Shuyi, Ooi, Eng Eong, Ohh, Michael (2021-04-08). Hypoxia and viral infectious diseases. JCI Insight 6 (7) : e147190. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis. © 2021, Huang et al.
Source Title: JCI Insight
ISSN: 2379-3708
DOI: 10.1172/jci.insight.147190
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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