Please use this identifier to cite or link to this item: https://doi.org/10.1172/jci.insight.147190
DC FieldValue
dc.titleHypoxia and viral infectious diseases
dc.contributor.authorHuang, Richard
dc.contributor.authorHuestis, Melissa
dc.contributor.authorGan, Esther Shuyi
dc.contributor.authorOoi, Eng Eong
dc.contributor.authorOhh, Michael
dc.date.accessioned2022-10-11T07:59:47Z
dc.date.available2022-10-11T07:59:47Z
dc.date.issued2021-04-08
dc.identifier.citationHuang, Richard, Huestis, Melissa, Gan, Esther Shuyi, Ooi, Eng Eong, Ohh, Michael (2021-04-08). Hypoxia and viral infectious diseases. JCI Insight 6 (7) : e147190. ScholarBank@NUS Repository. https://doi.org/10.1172/jci.insight.147190
dc.identifier.issn2379-3708
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232101
dc.description.abstractOxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis. © 2021, Huang et al.
dc.publisherAmerican Society for Clinical Investigation
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeReview
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1172/jci.insight.147190
dc.description.sourcetitleJCI Insight
dc.description.volume6
dc.description.issue7
dc.description.pagee147190
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