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Title: Comparative genomic analysis of bifidobacterium bifidum strains isolated from different niches
Authors: Lu, Wenwei
Pei, Zhangming
Zang, Mengning
Lee, Yuan-kun 
Zhao, Jianxin
Chen, Wei
Wang, Hongchao
Zhang, Hao
Keywords: Bifidobacterium bifidum
Comparative genomics
Issue Date: 25-Sep-2021
Publisher: MDPI
Citation: Lu, Wenwei, Pei, Zhangming, Zang, Mengning, Lee, Yuan-kun, Zhao, Jianxin, Chen, Wei, Wang, Hongchao, Zhang, Hao (2021-09-25). Comparative genomic analysis of bifidobacterium bifidum strains isolated from different niches. Genes 12 (10) : 1504. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The potential probiotic benefits of Bifidobacterium bifidum have received increasing attention recently. We used comparative genomic analysis to explore the differences in the genome and the physiological characteristics of B. bifidum isolated from the fecal samples of Chinese adults and infants. The relationships between genotypes and phenotypes were analyzed to assess the effects of isolation sources on the genetic variation of B. bifidum. The phylogenetic tree results indicated that the phylogeny of B. bifidum may be related to the geographical features of its isolation source. B. bifidum was found to have an open pan-genome and a conserved core genome. The genetic diversity of B. bifidum is mainly reflected in carbohydrate metabolism-and immune/competition-related factors, such as the glycoside hydrolase gene family, bacteriocin operons, antibiotic resistance genes, and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. Additionally, the type III A CRISPR-Cas system was discovered in B. bifidum for the first time. B. bifidum strains exhibited niche-specific characteristics, and the results of this study provide an improved understanding of the genetics of this species. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Genes
ISSN: 2073-4425
DOI: 10.3390/genes12101504
Rights: Attribution 4.0 International
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