Please use this identifier to cite or link to this item: https://doi.org/10.3390/genes12101504
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dc.titleComparative genomic analysis of bifidobacterium bifidum strains isolated from different niches
dc.contributor.authorLu, Wenwei
dc.contributor.authorPei, Zhangming
dc.contributor.authorZang, Mengning
dc.contributor.authorLee, Yuan-kun
dc.contributor.authorZhao, Jianxin
dc.contributor.authorChen, Wei
dc.contributor.authorWang, Hongchao
dc.contributor.authorZhang, Hao
dc.date.accessioned2022-10-11T07:52:51Z
dc.date.available2022-10-11T07:52:51Z
dc.date.issued2021-09-25
dc.identifier.citationLu, Wenwei, Pei, Zhangming, Zang, Mengning, Lee, Yuan-kun, Zhao, Jianxin, Chen, Wei, Wang, Hongchao, Zhang, Hao (2021-09-25). Comparative genomic analysis of bifidobacterium bifidum strains isolated from different niches. Genes 12 (10) : 1504. ScholarBank@NUS Repository. https://doi.org/10.3390/genes12101504
dc.identifier.issn2073-4425
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232010
dc.description.abstractThe potential probiotic benefits of Bifidobacterium bifidum have received increasing attention recently. We used comparative genomic analysis to explore the differences in the genome and the physiological characteristics of B. bifidum isolated from the fecal samples of Chinese adults and infants. The relationships between genotypes and phenotypes were analyzed to assess the effects of isolation sources on the genetic variation of B. bifidum. The phylogenetic tree results indicated that the phylogeny of B. bifidum may be related to the geographical features of its isolation source. B. bifidum was found to have an open pan-genome and a conserved core genome. The genetic diversity of B. bifidum is mainly reflected in carbohydrate metabolism-and immune/competition-related factors, such as the glycoside hydrolase gene family, bacteriocin operons, antibiotic resistance genes, and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. Additionally, the type III A CRISPR-Cas system was discovered in B. bifidum for the first time. B. bifidum strains exhibited niche-specific characteristics, and the results of this study provide an improved understanding of the genetics of this species. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.publisherMDPI
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectBifidobacterium bifidum
dc.subjectComparative genomics
dc.subjectDiversity
dc.subjectGenotype
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.3390/genes12101504
dc.description.sourcetitleGenes
dc.description.volume12
dc.description.issue10
dc.description.page1504
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