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Title: ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
Authors: Zhou, Qiling 
Yu, Miao
Tirado-Magallanes, Roberto 
Li, Bin
Kong, Lingshi 
Guo, Mingrui
Tan, Zi Hui 
Lee, Sanghoon 
Chai, Li
Numata, Akihiko 
Benoukraf, Touati 
Fullwood, Melissa Jane 
Osato, Motomi 
Ren, Bing
Tenen, Daniel G. 
Issue Date: 4-Jan-2021
Publisher: Nature Research
Citation: Zhou, Qiling, Yu, Miao, Tirado-Magallanes, Roberto, Li, Bin, Kong, Lingshi, Guo, Mingrui, Tan, Zi Hui, Lee, Sanghoon, Chai, Li, Numata, Akihiko, Benoukraf, Touati, Fullwood, Melissa Jane, Osato, Motomi, Ren, Bing, Tenen, Daniel G. (2021-01-04). ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function. Nature Communications 12 (1) : 43. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: CCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin–chromatin interactions, yet the mechanism regulating its binding to chromatin is unknown. We demonstrate that zinc finger protein 143 (ZNF143) is a key regulator for CTCF-bound promoter–enhancer loops. In the murine genome, a large percentage of CTCF and ZNF143 DNA binding motifs are distributed 37 bp apart in the convergent orientation. Furthermore, deletion of ZNF143 leads to loss of CTCF binding on promoter and enhancer regions associated with gene expression changes. CTCF-bound promoter–enhancer loops are also disrupted after excision of ZNF143. ZNF143-CTCF-bound promoter–enhancer loops regulate gene expression patterns essential for maintenance of murine hematopoietic stem and progenitor cell integrity. Our data suggest a common feature of gene regulation is that ZNF143 is a critical factor for CTCF-bound promoter–enhancer loops. © 2021, The Author(s).
Source Title: Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20282-1
Rights: Attribution 4.0 International
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