Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-20282-1
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dc.titleZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function
dc.contributor.authorZhou, Qiling
dc.contributor.authorYu, Miao
dc.contributor.authorTirado-Magallanes, Roberto
dc.contributor.authorLi, Bin
dc.contributor.authorKong, Lingshi
dc.contributor.authorGuo, Mingrui
dc.contributor.authorTan, Zi Hui
dc.contributor.authorLee, Sanghoon
dc.contributor.authorChai, Li
dc.contributor.authorNumata, Akihiko
dc.contributor.authorBenoukraf, Touati
dc.contributor.authorFullwood, Melissa Jane
dc.contributor.authorOsato, Motomi
dc.contributor.authorRen, Bing
dc.contributor.authorTenen, Daniel G.
dc.date.accessioned2022-10-11T07:50:52Z
dc.date.available2022-10-11T07:50:52Z
dc.date.issued2021-01-04
dc.identifier.citationZhou, Qiling, Yu, Miao, Tirado-Magallanes, Roberto, Li, Bin, Kong, Lingshi, Guo, Mingrui, Tan, Zi Hui, Lee, Sanghoon, Chai, Li, Numata, Akihiko, Benoukraf, Touati, Fullwood, Melissa Jane, Osato, Motomi, Ren, Bing, Tenen, Daniel G. (2021-01-04). ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function. Nature Communications 12 (1) : 43. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-20282-1
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/231981
dc.description.abstractCCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin–chromatin interactions, yet the mechanism regulating its binding to chromatin is unknown. We demonstrate that zinc finger protein 143 (ZNF143) is a key regulator for CTCF-bound promoter–enhancer loops. In the murine genome, a large percentage of CTCF and ZNF143 DNA binding motifs are distributed 37 bp apart in the convergent orientation. Furthermore, deletion of ZNF143 leads to loss of CTCF binding on promoter and enhancer regions associated with gene expression changes. CTCF-bound promoter–enhancer loops are also disrupted after excision of ZNF143. ZNF143-CTCF-bound promoter–enhancer loops regulate gene expression patterns essential for maintenance of murine hematopoietic stem and progenitor cell integrity. Our data suggest a common feature of gene regulation is that ZNF143 is a critical factor for CTCF-bound promoter–enhancer loops. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1038/s41467-020-20282-1
dc.description.sourcetitleNature Communications
dc.description.volume12
dc.description.issue1
dc.description.page43
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