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Title: A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy
Authors: Tang, Wei
Yang, Zhen
He, Liangcan
Deng, Liming
Fathi, Parinaz
Zhu, Shoujun
Li, Ling
Shen, Bo
Wang, Zhantong
Jacobson, Orit
Song, Jibin
Zou, Jianhua
Hu, Ping
Wang, Min
Mu, Jing
Cheng, Yaya
Ma, Yuanyuan
Tang, Longguang
Fan, Wenpei
Chen, Xiaoyuan 
Issue Date: 22-Jan-2021
Publisher: Nature Research
Citation: Tang, Wei, Yang, Zhen, He, Liangcan, Deng, Liming, Fathi, Parinaz, Zhu, Shoujun, Li, Ling, Shen, Bo, Wang, Zhantong, Jacobson, Orit, Song, Jibin, Zou, Jianhua, Hu, Ping, Wang, Min, Mu, Jing, Cheng, Yaya, Ma, Yuanyuan, Tang, Longguang, Fan, Wenpei, Chen, Xiaoyuan (2021-01-22). A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy. Nature Communications 12 (1) : 523. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution is to increase intratumoral oxygen supply. However, its effectiveness is often limited by the high metabolic demand for O2 by cancer cells. Herein, we develop a hybrid semiconducting organosilica-based O2 nanoeconomizer pHPFON-NO/O2 to combat tumor hypoxia. Our solution is twofold: first, the pHPFON-NO/O2 interacts with the acidic tumor microenvironment to release NO for endogenous O2 conservation; second, it releases O2 in response to mild photothermal effect to enable exogenous O2 infusion. Additionally, the photothermal effect can be increased to eradicate tumor residues with radioresistant properties due to other factors. This “reducing expenditure of O2 and broadening sources” strategy significantly alleviates tumor hypoxia in multiple ways, greatly enhances the efficacy of radiotherapy both in vitro and in vivo, and demonstrates the synergy between on-demand temperature-controlled photothermal and oxygen-elevated radiotherapy for complete tumor response. © 2021, The Author(s).
Source Title: Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20860-3
Rights: Attribution 4.0 International
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