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Title: Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
Authors: Tan, Yong Wah
Yam, Wan Keat
Kooi, Rachel Jia Wen
Westman, Jacob
Arbrandt, Gustav
Chu, Justin Jang Hann 
Issue Date: 6-May-2021
Publisher: Nature Research
Citation: Tan, Yong Wah, Yam, Wan Keat, Kooi, Rachel Jia Wen, Westman, Jacob, Arbrandt, Gustav, Chu, Justin Jang Hann (2021-05-06). Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition. Scientific Reports 11 (1) : 9719. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults. It has however emerged as a significant public health threat in recent years as outbreaks have been occurring regularly, especially in the Asia–Pacific. The disease can result from infections by a wide variety of human enteroviruses, particularly, Enterovirus A71 (EV-A71) has garnered more attention due to its association with severe disease in infected patients. Despite the potential to result severe neurological complications or even fatality, there is currently no effective antiviral for treatment of EV-A71 infections and the only vaccines available are restricted to distribution in China. In this study, we report the in vitro and in vivo evaluation of two candidate antiviral compounds active against EV-A71, a viral capsid inhibitor (G197) and a novel host-targeting phosphatidylinositol 4-kinase III beta inhibitor (N373) which, especially when used in combination, can significantly improve the survival and pathology of infected mice. © 2021, The Author(s).
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-89271-8
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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