Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-021-89271-8
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dc.titleNovel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
dc.contributor.authorTan, Yong Wah
dc.contributor.authorYam, Wan Keat
dc.contributor.authorKooi, Rachel Jia Wen
dc.contributor.authorWestman, Jacob
dc.contributor.authorArbrandt, Gustav
dc.contributor.authorChu, Justin Jang Hann
dc.date.accessioned2022-10-11T07:48:35Z
dc.date.available2022-10-11T07:48:35Z
dc.date.issued2021-05-06
dc.identifier.citationTan, Yong Wah, Yam, Wan Keat, Kooi, Rachel Jia Wen, Westman, Jacob, Arbrandt, Gustav, Chu, Justin Jang Hann (2021-05-06). Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition. Scientific Reports 11 (1) : 9719. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-89271-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/231949
dc.description.abstractThe Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults. It has however emerged as a significant public health threat in recent years as outbreaks have been occurring regularly, especially in the Asia–Pacific. The disease can result from infections by a wide variety of human enteroviruses, particularly, Enterovirus A71 (EV-A71) has garnered more attention due to its association with severe disease in infected patients. Despite the potential to result severe neurological complications or even fatality, there is currently no effective antiviral for treatment of EV-A71 infections and the only vaccines available are restricted to distribution in China. In this study, we report the in vitro and in vivo evaluation of two candidate antiviral compounds active against EV-A71, a viral capsid inhibitor (G197) and a novel host-targeting phosphatidylinositol 4-kinase III beta inhibitor (N373) which, especially when used in combination, can significantly improve the survival and pathology of infected mice. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1038/s41598-021-89271-8
dc.description.sourcetitleScientific Reports
dc.description.volume11
dc.description.issue1
dc.description.page9719
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