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Title: Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.
Authors: Rao, Vinay Kumar
Das, Dipanwita 
Taneja, Reshma 
Keywords: cancer
cytokine signaling
muscle wasting
transcription factors
Issue Date: 31-Aug-2022
Publisher: MDPI AG
Citation: Rao, Vinay Kumar, Das, Dipanwita, Taneja, Reshma (2022-08-31). Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.. Cancers (Basel) 14 (17) : 4258-. ScholarBank@NUS Repository.
Abstract: Cancer cachexia (CC) is a multifactorial syndrome characterized by a significant reduction in body weight that is predominantly caused by the loss of skeletal muscle and adipose tissue. Although the ill effects of cachexia are well known, the condition has been largely overlooked, in part due to its complex etiology, heterogeneity in mediators, and the involvement of diverse signaling pathways. For a long time, inflammatory factors have been the focus when developing therapeutics for the treatment of CC. Despite promising pre-clinical results, they have not yet advanced to the clinic. Developing new therapies requires a comprehensive understanding of how deregulated signaling leads to catabolic gene expression that underlies muscle wasting. Here, we review CC-associated signaling pathways and the transcriptional cascade triggered by inflammatory cytokines. Further, we highlight epigenetic factors involved in the transcription of catabolic genes in muscle wasting. We conclude with reflections on the directions that might pave the way for new therapeutic approaches to treat CC.
Source Title: Cancers (Basel)
ISSN: 20726694
DOI: 10.3390/cancers14174258
Appears in Collections:Staff Publications

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