Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers14174258
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dc.titleCancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.
dc.contributor.authorRao, Vinay Kumar
dc.contributor.authorDas, Dipanwita
dc.contributor.authorTaneja, Reshma
dc.date.accessioned2022-09-22T08:26:27Z
dc.date.available2022-09-22T08:26:27Z
dc.date.issued2022-08-31
dc.identifier.citationRao, Vinay Kumar, Das, Dipanwita, Taneja, Reshma (2022-08-31). Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.. Cancers (Basel) 14 (17) : 4258-. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers14174258
dc.identifier.issn20726694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/231204
dc.description.abstractCancer cachexia (CC) is a multifactorial syndrome characterized by a significant reduction in body weight that is predominantly caused by the loss of skeletal muscle and adipose tissue. Although the ill effects of cachexia are well known, the condition has been largely overlooked, in part due to its complex etiology, heterogeneity in mediators, and the involvement of diverse signaling pathways. For a long time, inflammatory factors have been the focus when developing therapeutics for the treatment of CC. Despite promising pre-clinical results, they have not yet advanced to the clinic. Developing new therapies requires a comprehensive understanding of how deregulated signaling leads to catabolic gene expression that underlies muscle wasting. Here, we review CC-associated signaling pathways and the transcriptional cascade triggered by inflammatory cytokines. Further, we highlight epigenetic factors involved in the transcription of catabolic genes in muscle wasting. We conclude with reflections on the directions that might pave the way for new therapeutic approaches to treat CC.
dc.publisherMDPI AG
dc.sourceElements
dc.subjectcancer
dc.subjectcytokine signaling
dc.subjectepigenetics
dc.subjectmuscle wasting
dc.subjecttranscription factors
dc.typeReview
dc.date.updated2022-09-22T07:34:05Z
dc.contributor.departmentDEPT OF PSYCHOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.3390/cancers14174258
dc.description.sourcetitleCancers (Basel)
dc.description.volume14
dc.description.issue17
dc.description.page4258-
dc.published.stateUnpublished
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