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https://doi.org/10.1097/MD.0000000000017020
Title: | Are heart doses associated with survival in patients with non-small cell lung cancer who received post-operative thoracic radiotherapy? A national population-based study | Authors: | Lee, Chia Ching Chua, Gail Wan Ying Zheng, Huili Soon, Yu Yang Foo, Ling Li Thiagarajan, Anuradha Yap, Swee Peng Siow, Tian Rui Ng, Wee Loon Chua, Kevin Lee Min Yip, Connie Chia, Brendan Seng Hup Ng, Yan Yee Master, Zubin Tan, Poh Wee Tan, Yun Inn Leong, Yuh Fun Loria, Joan Faith Evacula Vellayappan, Balamurugan Koh, Wee Yao Leong, Cheng Nang Tey, Jeremy Chee Seong Tham, Ivan Weng Keong Fong, Kam Weng |
Keywords: | Science & Technology Life Sciences & Biomedicine Medicine, General & Internal General & Internal Medicine myocardial infarct non-small cell lung cancer post-operative thoracic radiotherapy radiation dosimetry ADJUVANT CHEMOTHERAPY RADIATION-THERAPY CARDIAC TOXICITY ESCALATION TRIALS STAGE-II IMPACT EPIDEMIOLOGY SURVEILLANCE DISEASE |
Issue Date: | 1-Aug-2019 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Citation: | Lee, Chia Ching, Chua, Gail Wan Ying, Zheng, Huili, Soon, Yu Yang, Foo, Ling Li, Thiagarajan, Anuradha, Yap, Swee Peng, Siow, Tian Rui, Ng, Wee Loon, Chua, Kevin Lee Min, Yip, Connie, Chia, Brendan Seng Hup, Ng, Yan Yee, Master, Zubin, Tan, Poh Wee, Tan, Yun Inn, Leong, Yuh Fun, Loria, Joan Faith Evacula, Vellayappan, Balamurugan, Koh, Wee Yao, Leong, Cheng Nang, Tey, Jeremy Chee Seong, Tham, Ivan Weng Keong, Fong, Kam Weng (2019-08-01). Are heart doses associated with survival in patients with non-small cell lung cancer who received post-operative thoracic radiotherapy? A national population-based study. MEDICINE 98 (35). ScholarBank@NUS Repository. https://doi.org/10.1097/MD.0000000000017020 | Abstract: | The aim of this retrospective national cohort study is to assess the association between various radiation heart dosimetric parameters (RHDPs), acute myocardial infarct (AMI) and overall survival (OS) outcomes in non-small cell lung cancer (NSCLC) patients treated with post-operative thoracic radiotherapy (PORT) using contemporary radiation techniques.We identified patients with stage I to III NSCLC treated with PORT at the 2 national cancer institutions from 2007 to 2014. We linked their electronic medical records to the national AMI and death registries. Univariable Cox regression was performed to assess the association between various RHDPs, AMI, and OS.We included 43 eligible patients with median follow-up of 36.6 months. Median age was 64 years. Majority of the patients had pathological stage III disease (72%). Median prescription dose was 60Gy. Median mean heart dose (MHD) was 9.4Gy. There were no AMI events. The 5-year OS was 34%. Univariable Cox regression showed that age was significantly associated with OS (hazard ratio, 1.06; 95% confidence interval, 1.01 to 1.10; P = .008). Radiation heart doses, including MHD, volume of heart receiving at least 5, 25, 30, 40, 50Gy and dose to 30% of heart volume, were not significantly associated with OS.There is insufficient evidence to conclude that RHDPs are associated with OS for patients with NSCLC treated with PORT in this study. Studies with larger sample size and longer term follow-up are needed to assess AMI outcome. | Source Title: | MEDICINE | URI: | https://scholarbank.nus.edu.sg/handle/10635/229757 | ISSN: | 00257974 15365964 |
DOI: | 10.1097/MD.0000000000017020 |
Appears in Collections: | Staff Publications Elements |
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