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Title: Comparison of the preference-based EQ-5D-5L and SF-6D in patients with end-stage renal disease (ESRD)
Authors: Yang, Fan
Lau, Titus
Lee, Evan 
Vathsala, A 
Chia, Kee Seng 
Luo, Nan 
Keywords: ESRD
Discriminative ability
Issue Date: Dec-2015
Publisher: Springer Science and Business Media LLC
Citation: Yang, Fan, Lau, Titus, Lee, Evan, Vathsala, A, Chia, Kee Seng, Luo, Nan (2015-12). Comparison of the preference-based EQ-5D-5L and SF-6D in patients with end-stage renal disease (ESRD). EUROPEAN JOURNAL OF HEALTH ECONOMICS 16 (9) : 1019-1026. ScholarBank@NUS Repository.
Abstract: Objectives: The objective of this study was to compare the performance of the 5-level EuroQol 5-dimension (EQ-5D-5L) and the Short Form 6-dimension (SF-6D) instruments in assessing patients with end-stage renal disease (ESRD) in Singapore. Methods: In a cross-sectional study, ESRD patients attending a tertiary hospital were interviewed using a battery of questionnaires including the EQ-5D-5L, the kidney disease quality of life instrument (KDQOL-36), and questions assessing dialysis history and socio-demographic characteristics. We reviewed patients’ medical records for their clinical information. We assessed the construct validity of the EQ-5D-5L and SF-6D index scores and compared their ability to distinguish between patients differing in health status and the magnitude of between-group difference they quantified. Results: One hundred and fifty ESRD patients on dialysis (mean age, 60.1 years; female, 48.7 %) participated in the study. Both EQ-5D-5L and SF-6D demonstrated satisfactory known-groups validity; the EQ-5D-5L was more sensitive to differences in clinical outcomes and the SF-6D was more sensitive to differences in health outcomes measured by KDQOL scales. The intraclass correlation coefficient between the measures was 0.36. The differences in the EQ-5D-5L index score for patients in better and worse health status were greater than those measured by the SF-6D index score. Conclusions: Both EQ-5D-5L and SF-6D are valid instruments for assessing ESRD patients. However, the two preference-based measures cannot be used interchangeably and it appears that EQ-5D-5L would lead to more favorable cost-effectiveness results than SF-6D if they are used in economic evaluations of interventions for ESRD.
ISSN: 16187598
DOI: 10.1007/s10198-014-0664-7
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