Please use this identifier to cite or link to this item: https://doi.org/10.1111/tri.14158
Title: A meta-analysis on the prevalence of chronic kidney disease in liver transplant candidates and its associated risk factors and outcomes
Authors: Teo, Vanessa Xin Yi
Heng, Ryan Rui Yang
Tay, Phoebe Wen Lin
Ng, Cheng Han
Tan, Darren Jun Hao
Ong, Yuki
Tan, En Ying
Huang, Daniel 
Vathsala, Anantharaman 
Muthiah, Mark 
Tan, Eunice Xiang Xuan
Keywords: chronic kidney disease
hepatology
liver transplant
Issue Date: 7-Dec-2021
Publisher: WILEY
Citation: Teo, Vanessa Xin Yi, Heng, Ryan Rui Yang, Tay, Phoebe Wen Lin, Ng, Cheng Han, Tan, Darren Jun Hao, Ong, Yuki, Tan, En Ying, Huang, Daniel, Vathsala, Anantharaman, Muthiah, Mark, Tan, Eunice Xiang Xuan (2021-12-07). A meta-analysis on the prevalence of chronic kidney disease in liver transplant candidates and its associated risk factors and outcomes. TRANSPLANT INTERNATIONAL 34 (12) : 2515-2523. ScholarBank@NUS Repository. https://doi.org/10.1111/tri.14158
Abstract: Pre-liver transplant (LT) chronic kidney disease (CKD) has emerged as a leading cause of post-operative morbidity. We aimed to report the prevalence, associated risk factors, and clinical outcomes in patients with pre-LT CKD. Meta-analysis and systematic review were conducted for included cohort and cross-sectional studies. Studies comparing healthy and patients with s pre-LT CKD were included. Outcomes were assessed with pooled hazard ratios. 15 studies were included, consisting of 82,432 LT patients and 26,754 with pre-LT CKD. Pooled prevalence of pre-LT CKD was 22.35% (CI: 15.30%–32.71%). Diabetes mellitus, hypertension, viral hepatitis, and non-alcoholic fatty liver disease, and older age were associated with increased risk of pre-LT CKD: (OR 1.72 CI: 1.15–2.56, P = 0.01), (OR 2.23 CI: 1.76–2.83, P < 0.01), (OR 1.09; CI: 1.05–1.13, P < 0.01), (OR 1.73; CI: 1.10–2.71 P = 0.03), and (MD: 2.92 years; CI: 1.29–4.55years; P < 0.01) respectively. Pre-LT CKD was significantly associated with increased mortality (HR 1.38; CI: 1.2–1.59; P < 0.01), post-LT end-stage renal disease and post-LT CKD. Almost a quarter of pre-LT patients have CKD and it is significantly associated with post-operative morbidity and mortality. However, long-term outcomes remain unclear due to a lack of studies reporting such outcomes.
Source Title: TRANSPLANT INTERNATIONAL
URI: https://scholarbank.nus.edu.sg/handle/10635/229172
ISSN: 0934-0874
1432-2277
DOI: 10.1111/tri.14158
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