Please use this identifier to cite or link to this item: https://doi.org/10.1093/rheumatology/keaa504
Title: Takotsubo syndrome and rheumatic diseases - a critical systematic review
Authors: Lin, Weiqin 
Tay, Sen Hee 
Mak, Anselm 
Keywords: Takotsubo syndrome
cardiomyopathy
rheumatological
Sjogren's syndrome
Takayasu's arteritis
autoimmunity
lupus
Issue Date: 1-Jan-2021
Publisher: OXFORD UNIV PRESS
Citation: Lin, Weiqin, Tay, Sen Hee, Mak, Anselm (2021-01-01). Takotsubo syndrome and rheumatic diseases - a critical systematic review. RHEUMATOLOGY 60 (1) : 11-22. ScholarBank@NUS Repository. https://doi.org/10.1093/rheumatology/keaa504
Abstract: Since its description in 1990, Takotsubo syndrome (TTS), an acute cardiac condition triggered by physical or emotional stress, has been believed to be related to catecholamine surge from overwhelming sympathetic activity. While symptomatology, biochemical features, ECG and echocardiogram alterations are largely indistinguishable from acute coronary syndrome, the absence of culprit coronary lesions often necessitates further investigations, uncovering underlying inflammatory processes. Mechanistically, animal models of TTS reveal early neutrophil infiltration followed by staged ingression of two subtypes of macrophages (M1, M2) mediating initial acute inflammatory changes (M1), followed by switching to anti-inflammatory signals (M2) that enhance myocardial tissue recovery. Here, we begin with a description of two TTS patients with primary Sjögren's syndrome and Takayasu's arteritis, followed by a systematic literature review that summarizes the demographic and clinical features of TTS patients with rheumatological conditions. Potential impact of disease manifestations and treatment of rheumatological conditions on TTS are critically discussed.
Source Title: RHEUMATOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/228808
ISSN: 1462-0324
1462-0332
DOI: 10.1093/rheumatology/keaa504
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