Please use this identifier to cite or link to this item: https://doi.org/10.3390/jcm11113063
Title: Risk Factors for Mortality in Cardiac Implantable Electronic Device (CIED) Infections: A Systematic Review and Meta-Analysis
Authors: Ngiam, Jinghao Nicholas
Liong, Tze Sian
Sim, Meng Ying
Chew, Nicholas WS
Sia, Ching-Hui 
Chan, Siew Pang 
Lim, Toon Wei 
Yeo, Tiong-Cheng 
Tambyah, Paul Anantharajah 
Loh, Poay Huan
Poh, Kian Keong 
Kong, William KF
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
cardiac implantable electronic device
infection
mortality
outcomes
TRANSVENOUS LEAD EXTRACTION
PERMANENT PACEMAKER
1-YEAR MORTALITY
ENDOCARDITIS
PREDICTORS
MANAGEMENT
TRENDS
IMPACT
RATES
Issue Date: 1-Jun-2022
Publisher: MDPI
Citation: Ngiam, Jinghao Nicholas, Liong, Tze Sian, Sim, Meng Ying, Chew, Nicholas WS, Sia, Ching-Hui, Chan, Siew Pang, Lim, Toon Wei, Yeo, Tiong-Cheng, Tambyah, Paul Anantharajah, Loh, Poay Huan, Poh, Kian Keong, Kong, William KF (2022-06-01). Risk Factors for Mortality in Cardiac Implantable Electronic Device (CIED) Infections: A Systematic Review and Meta-Analysis. JOURNAL OF CLINICAL MEDICINE 11 (11). ScholarBank@NUS Repository. https://doi.org/10.3390/jcm11113063
Abstract: BACKGROUND: Infections following cardiac implantable electronic device (CIED) implantation can require surgical device removal and often results in significant cost, morbidity, and potentially mortality. We aimed to systemically review the literature and identify risk factors associated with mortality following CIED infection. METHODS: Electronic searches (up to June 2021) were performed on PubMed and Scopus. Twelve studies (10 retrospective, 2 prospective cohort studies) were included for analysis. Meta-analysis was conducted with the restricted maximum likelihood method, with mortality as the outcome. The overall mortality was 13.7% (438/1398) following CIED infection. RESULTS: On meta-analysis, the male sex (OR 0.77, 95%CI 0.57-1.01, I2 = 2.2%) appeared to have lower odds for mortality, while diabetes mellitus appeared to be associated with higher mortality (OR 1.47, 95%CI 0.67-3.26, I2 = 81.4%), although these trends did not reach statistical significance. Staphylococcus aureus as the causative organism (OR 2.71, 95%CI 1.76-4.19, I2 = 0.0%), presence of heart failure (OR 1.92, 95%CI 1.42-4.19, I2 = 0.0%) and embolic phenomena (OR 4.00, 95%CI 1.67-9.56, I2 = 69.8%) were associated with higher mortality. Surgical removal of CIED was associated with lower mortality compared with conservative management with antibiotics alone (OR 0.22, 95%CI 0.09-0.50, I2 = 62.8%). CONCLUSION: We identified important risk factors associated with mortality in CIED infections, including Staphyloccocus aureus as the causative organism, and the presence of complications, such as heart failure and embolic phenomena. Surgery, where possible, was associated with better outcomes.
Source Title: JOURNAL OF CLINICAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/228514
ISSN: 2077-0383
DOI: 10.3390/jcm11113063
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Risk Factors for Mortality in Cardiac Implantable Electronic Device (CIED) Infections A Systematic Review and Meta-Analysis.pdfPublished version2.98 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

1
checked on Feb 3, 2023

Page view(s)

55
checked on Feb 2, 2023

Download(s)

9
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.