Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mtla.2020.100604
Title: Osteogenic potential of graphene coated titanium is independent of transfer technique
Authors: NILESHKUMAR DUBEY 
JULIEN LUC PAUL MORIN 
EMMA KIM LUONG-VAN C 
AGARWALLA SHRUTI VIDHAWAN 
NIKOLAOS SILIKAS
Castro Neto,Antonio Helio 
Vinicius Rosa 
Keywords: Osteointegration
Implants
Osteogenesis
Coating
Surface modification
Differentiation
nanomaterial
Issue Date: 28-Jan-2020
Publisher: Elsevier
Citation: NILESHKUMAR DUBEY, JULIEN LUC PAUL MORIN, EMMA KIM LUONG-VAN C, AGARWALLA SHRUTI VIDHAWAN, NIKOLAOS SILIKAS, Castro Neto,Antonio Helio, Vinicius Rosa (2020-01-28). Osteogenic potential of graphene coated titanium is independent of transfer technique. Materialia : 1006045. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mtla.2020.100604
Abstract: The rapid integration of titanium implants into native bone remains a challenge in orthopedics and dental im- plantology. Several surface modifications have been attempted, but with limited success. Graphene coating has emerged as a candidate for shortening integration time due to its osteogenic potential. The wet transfer technique (WGp) is widely used to demonstrate graphene’s osteogenic potential but it is laborious and time-consuming, hence compromising industrial scalability and market adoption. Moreover, this transfer method traps water be- tween the coating and the target substrate, which can further deteriorate the coating and compromise its clinical translation even more. Alternatively, the dry transfer (DGp) method, based on the mechanized application of pressurized heat, allows graphene films to be transferred directly from a tape onto titanium in few minutes at a low cost. Here, we show that a single dry transfer procedure can coat > 90% of titanium samples with graphene. Compared with uncoated titanium, DGp increased the expression of cellular adhesion and collagen-related genes, collagen production, and bone formation. Raman and atomic force microscopy showed that cellular structures and stiffness were similar to those observed on uncoated titanium and X-ray powder diffraction confirmed that DGp favors the early formation of octacalcium phosphate. The results demonstrating the potential of DGp were similar to WGp, confirming that the changes in transfer procedures performed to improve the likelihood of in- dustrial scalability and clinical translation do not compromise the osteogenic potential of the graphene coating on titanium.
Source Title: Materialia
URI: https://scholarbank.nus.edu.sg/handle/10635/227657
DOI: 10.1016/j.mtla.2020.100604
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Osteogenic potential of graphene coated titanium is independent of transfer technique - Scholarbank.pdfAccepted version874.03 kBAdobe PDF

OPEN

Post-printView/Download

SCOPUSTM   
Citations

8
checked on Dec 2, 2022

Page view(s)

47
checked on Dec 1, 2022

Download(s)

1
checked on Dec 1, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.