Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms222111777
Title: Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
Authors: Boey, Adrian 
Leong, Shu Qing
Bhave, Sayali 
Ho, Han Kiat 
Keywords: liver fibrosis
cerium oxide nanoparticles
nanoparticles
Issue Date: 1-Nov-2021
Publisher: MDPI
Citation: Boey, Adrian, Leong, Shu Qing, Bhave, Sayali, Ho, Han Kiat (2021-11-01). Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 (21). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms222111777
Abstract: Exposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Among NPs, cerium oxide nanoparticles (CeO2 NP) possess strong antioxidant properties and have shown to alleviate certain pathological conditions. Herein, we show that the presence of cubic 25 nm CeO2 NP was able to reduce TGF-β-mediated activation in the cultured hepatic stellate cell line LX2 by reducing oxidative stress levels and TGF-β-mediated signalling. These cells displayed reduced classical liver fibrosis phenotypes, such as diminished fibrogenesis, altered matrix degradation, decreased cell motility, modified contractability and potentially lowered autophagy. These findings demonstrate that CeO2 NP may be able to ameliorate hepatic fibrosis and suggest a possible therapeutic pathway for an otherwise difficult-to-treat condition.
Source Title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/227178
ISBN: 1422-006
ISSN: 1661-6596
DOI: 10.3390/ijms222111777
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