Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms222111777
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dc.titleCerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
dc.contributor.authorBoey, Adrian
dc.contributor.authorLeong, Shu Qing
dc.contributor.authorBhave, Sayali
dc.contributor.authorHo, Han Kiat
dc.date.accessioned2022-06-17T05:46:59Z
dc.date.available2022-06-17T05:46:59Z
dc.date.issued2021-11-01
dc.identifier.citationBoey, Adrian, Leong, Shu Qing, Bhave, Sayali, Ho, Han Kiat (2021-11-01). Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 (21). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms222111777
dc.identifier.isbn1422-006
dc.identifier.issn1661-6596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227178
dc.description.abstractExposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Among NPs, cerium oxide nanoparticles (CeO2 NP) possess strong antioxidant properties and have shown to alleviate certain pathological conditions. Herein, we show that the presence of cubic 25 nm CeO2 NP was able to reduce TGF-β-mediated activation in the cultured hepatic stellate cell line LX2 by reducing oxidative stress levels and TGF-β-mediated signalling. These cells displayed reduced classical liver fibrosis phenotypes, such as diminished fibrogenesis, altered matrix degradation, decreased cell motility, modified contractability and potentially lowered autophagy. These findings demonstrate that CeO2 NP may be able to ameliorate hepatic fibrosis and suggest a possible therapeutic pathway for an otherwise difficult-to-treat condition.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectliver fibrosis
dc.subjectcerium oxide nanoparticles
dc.subjectnanoparticles
dc.typeArticle
dc.date.updated2022-06-17T05:33:01Z
dc.contributor.departmentDEPT OF PHARMACY
dc.contributor.departmentOFFICE OF STUDENT AFFAIRS
dc.description.doi10.3390/ijms222111777
dc.description.sourcetitleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.description.volume22
dc.description.issue21
dc.published.statePublished
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