Please use this identifier to cite or link to this item: https://doi.org/10.2147/JAA.S130459
Title: Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma
Authors: Goh, Ken Junyang
Yii, Anthony Chau Ang
Lapperre, Therese Sophie 
Chan, Adrian KW
Chew, Fook Tim 
Chotirmall, Sanjay H
Koh, Mariko Siyue
Keywords: atopy
airway
fungus
Aspergillus
outcomes
prognosis
Issue Date: 1-Jan-2017
Publisher: DOVE MEDICAL PRESS LTD
Citation: Goh, Ken Junyang, Yii, Anthony Chau Ang, Lapperre, Therese Sophie, Chan, Adrian KW, Chew, Fook Tim, Chotirmall, Sanjay H, Koh, Mariko Siyue (2017-01-01). Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma. JOURNAL OF ASTHMA AND ALLERGY 10 : 131-140. ScholarBank@NUS Repository. https://doi.org/10.2147/JAA.S130459
Abstract: Background: Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting. Methods: We conducted a cross-sectional study of patients receiving step 4 or 5 Global Initiative for Asthma treatment. Univariate and multivariate analyses were performed to assess the association between sensitization to a specific identifiable allergen by skin prick test (SPT) and uncontrolled asthma (defined in our study as the use of ≥2 steroid bursts or hospitalization in the past year, a history of near-fatal asthma or evidence of airflow obstruction on spirometry). Results: Two hundred and six severe asthma patients (mean age 45±17 years, 99 [48.1%] male) were evaluated. Of them, 78.2% had a positive SPT to one or more allergens. The most common allergen to which patients were sensitized was house dust mites (Blomia tropicalis, Dermatophagoides pteronyssinus and Dermatophagoides farinae). Also, 11.7% were sensitized to Aspergillus species. On multivariate analysis, Aspergillus sensitization was associated with uncontrolled asthma (odds ratio 6.07, 95% confidence interval 1.80–20.51). In particular, Aspergillus sensitization was independently associated with the use of ≥2 steroid bursts in the past year (odds ratio 3.05, 95% confidence interval 1.04–8.95). No similar associations of uncontrolled asthma with sensitization to any other allergens were found. Conclusion: High allergen, specifically Aspergillus sensitization was observed in the Asian population with severe asthma by SPT. Aspergillus sensitization was specifically associated with frequent exacerbations and a greater corticosteroid requirement. An improved understanding of the severe asthma with Aspergillus sensitization phenotype is warranted, which is likely a subgroup of severe asthma with fungal sensitization.
Source Title: JOURNAL OF ASTHMA AND ALLERGY
URI: https://scholarbank.nus.edu.sg/handle/10635/226981
ISSN: 1178-6965
DOI: 10.2147/JAA.S130459
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Sensitization to iAspergillusi species is associated with frequent exacerbations in severe asthma.pdf291.31 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

45
checked on Feb 3, 2023

Page view(s)

51
checked on Feb 2, 2023

Download(s)

1
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.