Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11046-021-00532-6
Title: Sensitization to Airborne Fungal Allergens Associates with Asthma and Allergic Rhinitis Presentation and Severity in the Singaporean/Malaysian Population
Authors: Sio, Yang Yie 
Pang, Sze Lei 
Say, Yee-How 
Teh, Keng Foo
Wong, Yi Ru
Shah, Smyrna Moti Rawanan
Reginald, Kavita
Chew, Fook Tim 
Keywords: Allergy
Fungi
Sensitization
Aspergillus
Curvularia
Issue Date: 13-Jul-2021
Publisher: SPRINGER
Citation: Sio, Yang Yie, Pang, Sze Lei, Say, Yee-How, Teh, Keng Foo, Wong, Yi Ru, Shah, Smyrna Moti Rawanan, Reginald, Kavita, Chew, Fook Tim (2021-07-13). Sensitization to Airborne Fungal Allergens Associates with Asthma and Allergic Rhinitis Presentation and Severity in the Singaporean/Malaysian Population. MYCOPATHOLOGIA 186 (5) : 583-588. ScholarBank@NUS Repository. https://doi.org/10.1007/s11046-021-00532-6
Abstract: Fungal spores and conidia are the major components of total airspora in the tropical Asia environment, and their sensitization patterns are often associated with allergic diseases such as asthma, allergic rhinitis (AR), and atopic dermatitis. Hence, we recruited a cross-sectional cohort of 9223 Singapore/Malaysia Chinese adults and assessed their sensitization against Curvularia lunata allergen using the skin prick test approach. A subset of this cohort (n = 254) was also screened for specific Immunoglobulin E (sIgE) titers against a panel of 11 fungal allergens. We found significant association of Curvularia lunata sensitization with the risk of asthma (OR = 1.66, 95% CI: 1.17–2.33; p = 0.00391) and AR (OR = 1.69, 95% CI: 1.18–2.41; p = 0.00396). Among asthmatic patients (n = 1680), Curvularia lunata sensitization also increased frequencies of wheezing symptoms (OR = 1.81, 95% CI: 1.05–2.96; p = 0.0239), general practitioner/specialist visits (OR = 2.37, 95% CI: 1.13–4.61; p = 0.0157), and other asthma-related exacerbation events (OR = 2.14, 95% CI: 1.04–4.10; p = 0.0289). In our serum cohort, sensitization to Aspergillus spp. was the most common fungal sensitization, with 23.6% (n = 60) had a class 3 and above sensitization (positive sensitization; sIgE titers of > 3.5 kU/L) against this allergen. Increasing sIgE titer against Aspergillus spp. was also correlated with increased AR risk and AR-related symptoms. In conclusion, our findings emphasize an important role of fungal sensitization in the manifestations of asthma and AR in the Southeast Asian Chinese population.
Source Title: MYCOPATHOLOGIA
URI: https://scholarbank.nus.edu.sg/handle/10635/226958
ISSN: 0301-486X
1573-0832
DOI: 10.1007/s11046-021-00532-6
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