Please use this identifier to cite or link to this item: https://doi.org/10.1186/s40779-021-00342-3
Title: Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice
Authors: Pang, Natalie Yan-Lin
Pang, Alexander Shao-Rong
Chow, Vincent T 
Wang, De-Yun 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
SARS-CoV-2
Coronavirus disease 2019
Neutralising antibodies
Persistence
Spike glycoprotein
Receptor-binding domain
B cells
T cells
Convalescent plasma
SERUM ANTIBODY
COVID-19
IGG
INFECTION
RESPONSES
SPIKE
Issue Date: 31-Aug-2021
Publisher: BMC
Citation: Pang, Natalie Yan-Lin, Pang, Alexander Shao-Rong, Chow, Vincent T, Wang, De-Yun (2021-08-31). Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice. MILITARY MEDICAL RESEARCH 8 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s40779-021-00342-3
Abstract: SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and livelihoods of millions worldwide. As of 23 August 2021, a total of 211,373,303 COVID-19 cases have been confirmed globally with a death toll of 4,424,341. A strong understanding of the infection pathway of SARS-CoV-2, and how our immune system responds to the virus is highly pertinent for guiding the development and improvement of effective treatments. In this review, we discuss the current understanding of neutralising antibodies (NAbs) and their implications in clinical practice. The aspects include the pathophysiology of the immune response, particularly humoral adaptive immunity and the roles of NAbs from B cells in infection clearance. We summarise the onset and persistence of IgA, IgM and IgG antibodies, and we explore their roles in neutralising SARS-CoV-2, their persistence in convalescent individuals, and in reinfection. Furthermore, we also review the applications of neutralising antibodies in the clinical setting—from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion.
Source Title: MILITARY MEDICAL RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/226769
ISSN: 20957467
20549369
DOI: 10.1186/s40779-021-00342-3
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