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https://doi.org/10.1186/s40779-021-00342-3
Title: | Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice | Authors: | Pang, Natalie Yan-Lin Pang, Alexander Shao-Rong Chow, Vincent T Wang, De-Yun |
Keywords: | Science & Technology Life Sciences & Biomedicine Medicine, General & Internal General & Internal Medicine SARS-CoV-2 Coronavirus disease 2019 Neutralising antibodies Persistence Spike glycoprotein Receptor-binding domain B cells T cells Convalescent plasma SERUM ANTIBODY COVID-19 IGG INFECTION RESPONSES SPIKE |
Issue Date: | 31-Aug-2021 | Publisher: | BMC | Citation: | Pang, Natalie Yan-Lin, Pang, Alexander Shao-Rong, Chow, Vincent T, Wang, De-Yun (2021-08-31). Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice. MILITARY MEDICAL RESEARCH 8 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s40779-021-00342-3 | Abstract: | SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and livelihoods of millions worldwide. As of 23 August 2021, a total of 211,373,303 COVID-19 cases have been confirmed globally with a death toll of 4,424,341. A strong understanding of the infection pathway of SARS-CoV-2, and how our immune system responds to the virus is highly pertinent for guiding the development and improvement of effective treatments. In this review, we discuss the current understanding of neutralising antibodies (NAbs) and their implications in clinical practice. The aspects include the pathophysiology of the immune response, particularly humoral adaptive immunity and the roles of NAbs from B cells in infection clearance. We summarise the onset and persistence of IgA, IgM and IgG antibodies, and we explore their roles in neutralising SARS-CoV-2, their persistence in convalescent individuals, and in reinfection. Furthermore, we also review the applications of neutralising antibodies in the clinical setting—from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion. | Source Title: | MILITARY MEDICAL RESEARCH | URI: | https://scholarbank.nus.edu.sg/handle/10635/226769 | ISSN: | 20957467 20549369 |
DOI: | 10.1186/s40779-021-00342-3 |
Appears in Collections: | Elements Staff Publications |
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