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https://doi.org/10.1186/s13104-022-06033-z
Title: | Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline | Authors: | Grafton-Clarke, C Njoku, P Aben, JP Ledoux, L Zhong, L Westenberg, J Swift, A Archer, G Wild, J Hose, R Flather, M Vassiliou, VS Garg, P |
Keywords: | Aortic stenosis Cardiac MRI Validation Aortic Valve Aortic Valve Stenosis Blood Flow Velocity Echocardiography Echocardiography, Doppler Humans |
Issue Date: | 1-Dec-2022 | Publisher: | Springer Science and Business Media LLC | Citation: | Grafton-Clarke, C, Njoku, P, Aben, JP, Ledoux, L, Zhong, L, Westenberg, J, Swift, A, Archer, G, Wild, J, Hose, R, Flather, M, Vassiliou, VS, Garg, P (2022-12-01). Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline. BMC Research Notes 15 (1) : 151-. ScholarBank@NUS Repository. https://doi.org/10.1186/s13104-022-06033-z | Abstract: | Objective: Doppler echocardiographic aortic valve peak velocity and peak pressure gradient assessment across the aortic valve (AV) is the mainstay for diagnosing aortic stenosis. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is emerging as a valuable diagnostic tool for estimating the peak pressure drop across the aortic valve, but assessment remains cumbersome. We aimed to validate a novel semi-automated pipeline 4D flow CMR method of assessing peak aortic value pressure gradient (AVPG) using the commercially available software solution, CAAS MR Solutions, against invasive angiographic methods. Results: We enrolled 11 patients with severe AS on echocardiography from the EurValve programme. All patients had pre-intervention doppler echocardiography, invasive cardiac catheterisation with peak pressure drop assessment across the AV and 4D flow CMR. The peak AVPG was 51.9 ± 35.2 mmHg using the invasive pressure drop method and 52.2 ± 29.2 mmHg for the 4D flow CMR method (semi-automated pipeline), with good correlation between the two methods (r = 0.70, p = 0.017). Assessment of AVPG by 4D flow CMR using the novel semi-automated pipeline method shows excellent agreement to invasive assessment when compared to doppler-based methods and advocate for its use as complementary to echocardiography. | Source Title: | BMC Research Notes | URI: | https://scholarbank.nus.edu.sg/handle/10635/226754 | ISSN: | 17560500 | DOI: | 10.1186/s13104-022-06033-z |
Appears in Collections: | Staff Publications Elements |
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