Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s13104-022-06033-z
DC Field | Value | |
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dc.title | Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline | |
dc.contributor.author | Grafton-Clarke, C | |
dc.contributor.author | Njoku, P | |
dc.contributor.author | Aben, JP | |
dc.contributor.author | Ledoux, L | |
dc.contributor.author | Zhong, L | |
dc.contributor.author | Westenberg, J | |
dc.contributor.author | Swift, A | |
dc.contributor.author | Archer, G | |
dc.contributor.author | Wild, J | |
dc.contributor.author | Hose, R | |
dc.contributor.author | Flather, M | |
dc.contributor.author | Vassiliou, VS | |
dc.contributor.author | Garg, P | |
dc.date.accessioned | 2022-06-08T08:12:23Z | |
dc.date.available | 2022-06-08T08:12:23Z | |
dc.date.issued | 2022-12-01 | |
dc.identifier.citation | Grafton-Clarke, C, Njoku, P, Aben, JP, Ledoux, L, Zhong, L, Westenberg, J, Swift, A, Archer, G, Wild, J, Hose, R, Flather, M, Vassiliou, VS, Garg, P (2022-12-01). Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline. BMC Research Notes 15 (1) : 151-. ScholarBank@NUS Repository. https://doi.org/10.1186/s13104-022-06033-z | |
dc.identifier.issn | 17560500 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/226754 | |
dc.description.abstract | Objective: Doppler echocardiographic aortic valve peak velocity and peak pressure gradient assessment across the aortic valve (AV) is the mainstay for diagnosing aortic stenosis. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is emerging as a valuable diagnostic tool for estimating the peak pressure drop across the aortic valve, but assessment remains cumbersome. We aimed to validate a novel semi-automated pipeline 4D flow CMR method of assessing peak aortic value pressure gradient (AVPG) using the commercially available software solution, CAAS MR Solutions, against invasive angiographic methods. Results: We enrolled 11 patients with severe AS on echocardiography from the EurValve programme. All patients had pre-intervention doppler echocardiography, invasive cardiac catheterisation with peak pressure drop assessment across the AV and 4D flow CMR. The peak AVPG was 51.9 ± 35.2 mmHg using the invasive pressure drop method and 52.2 ± 29.2 mmHg for the 4D flow CMR method (semi-automated pipeline), with good correlation between the two methods (r = 0.70, p = 0.017). Assessment of AVPG by 4D flow CMR using the novel semi-automated pipeline method shows excellent agreement to invasive assessment when compared to doppler-based methods and advocate for its use as complementary to echocardiography. | |
dc.publisher | Springer Science and Business Media LLC | |
dc.source | Elements | |
dc.subject | Aortic stenosis | |
dc.subject | Cardiac MRI | |
dc.subject | Validation | |
dc.subject | Aortic Valve | |
dc.subject | Aortic Valve Stenosis | |
dc.subject | Blood Flow Velocity | |
dc.subject | Echocardiography | |
dc.subject | Echocardiography, Doppler | |
dc.subject | Humans | |
dc.type | Article | |
dc.date.updated | 2022-06-07T06:06:16Z | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1186/s13104-022-06033-z | |
dc.description.sourcetitle | BMC Research Notes | |
dc.description.volume | 15 | |
dc.description.issue | 1 | |
dc.description.page | 151- | |
dc.published.state | Accepted | |
Appears in Collections: | Staff Publications Elements |
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Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline.pdf | Published version | 1.17 MB | Adobe PDF | OPEN | None | View/Download |
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