Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms21072391
Title: Hepatic Lipid Catabolism via PPAR alpha-Lysosomal Crosstalk
Authors: Sinha, Rohit A 
Rajak, Sangam
Singh, Brijesh K 
Yen, Paul M 
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
PPARs
lysosomes
NCoR1
PGC1 alpha
lipophagy
peroxisomes
autophagy
NAFLD
ACTIVATED RECEPTOR-ALPHA
NUCLEAR RECEPTORS
AUTOPHAGY
LIVER
METABOLISM
STEATOHEPATITIS
LIPOPHAGY
LIPOLYSIS
STORAGE
MICE
Issue Date: 1-Apr-2020
Publisher: MDPI
Citation: Sinha, Rohit A, Rajak, Sangam, Singh, Brijesh K, Yen, Paul M (2020-04-01). Hepatic Lipid Catabolism via PPAR alpha-Lysosomal Crosstalk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms21072391
Abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARa has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD).
Source Title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/226725
ISSN: 16616596
14220067
DOI: 10.3390/ijms21072391
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