Please use this identifier to cite or link to this item:
https://doi.org/10.3390/ijms21072391
DC Field | Value | |
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dc.title | Hepatic Lipid Catabolism via PPAR alpha-Lysosomal Crosstalk | |
dc.contributor.author | Sinha, Rohit A | |
dc.contributor.author | Rajak, Sangam | |
dc.contributor.author | Singh, Brijesh K | |
dc.contributor.author | Yen, Paul M | |
dc.date.accessioned | 2022-06-08T06:14:25Z | |
dc.date.available | 2022-06-08T06:14:25Z | |
dc.date.issued | 2020-04-01 | |
dc.identifier.citation | Sinha, Rohit A, Rajak, Sangam, Singh, Brijesh K, Yen, Paul M (2020-04-01). Hepatic Lipid Catabolism via PPAR alpha-Lysosomal Crosstalk. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms21072391 | |
dc.identifier.issn | 16616596 | |
dc.identifier.issn | 14220067 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/226725 | |
dc.description.abstract | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARa has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD). | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Physical Sciences | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | Chemistry | |
dc.subject | PPARs | |
dc.subject | lysosomes | |
dc.subject | NCoR1 | |
dc.subject | PGC1 alpha | |
dc.subject | lipophagy | |
dc.subject | peroxisomes | |
dc.subject | autophagy | |
dc.subject | NAFLD | |
dc.subject | ACTIVATED RECEPTOR-ALPHA | |
dc.subject | NUCLEAR RECEPTORS | |
dc.subject | AUTOPHAGY | |
dc.subject | LIVER | |
dc.subject | METABOLISM | |
dc.subject | STEATOHEPATITIS | |
dc.subject | LIPOPHAGY | |
dc.subject | LIPOLYSIS | |
dc.subject | STORAGE | |
dc.subject | MICE | |
dc.type | Review | |
dc.date.updated | 2022-06-07T06:25:33Z | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.3390/ijms21072391 | |
dc.description.sourcetitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | |
dc.description.volume | 21 | |
dc.description.issue | 7 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. .pdf | Published version | 567.15 kB | Adobe PDF | OPEN | Published | View/Download |
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