Please use this identifier to cite or link to this item: https://doi.org/10.5761/atcs.oa.21-00132
Title: N-Acetylcysteine's Renoprotective Effect in Cardiac Surgery: A Systematic Review and Meta-Analysis
Authors: Tan, Ying Kiat
Luo, HaiDong 
Kang, Giap Swee 
Teoh, Kristine LK 
Kofidis, Theo 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Surgery
Cardiovascular System & Cardiology
cardiac surgery
acute kidney injury
N-acetylcysteine
Commons Attribution-NonCommercial-
ACUTE KIDNEY INJURY
PREVENT RENAL DYSFUNCTION
HIGH-RISK PATIENTS
CONTROLLED-TRIAL
FAILURE
BYPASS
Issue Date: 1-Jan-2022
Publisher: Int Acad Publishing Co Ltd
Citation: Tan, Ying Kiat, Luo, HaiDong, Kang, Giap Swee, Teoh, Kristine LK, Kofidis, Theo (2022-01-01). N-Acetylcysteine's Renoprotective Effect in Cardiac Surgery: A Systematic Review and Meta-Analysis. ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 28 (2) : 138-145. ScholarBank@NUS Repository. https://doi.org/10.5761/atcs.oa.21-00132
Abstract: Objective: To examine N-acetylcysteine’s (NAC’s) renoprotective effect in adult cardiac surgery Methods: PubMed, Ovid Medline, and Embase were searched for randomized controlled trials published between January 1990 and May 2021 that investigated the effect of NAC in preventing acute kidney injury (AKI) in patients undergoing cardiac surgery. The inclusion criterion was studies that assessed the effect of NAC in comparison to placebo by measuring the incidence of AKI. Results: Overall meta-analytic estimates of all 10 included trials showed that NAC did not have a significant effect (odds ratio [OR]: 0.84, 95% confidence interval [CI]: 0.64–1.10) on AKI. Further subgroup analysis did not show a significant benefit of NAC in preventing AKI. Conclusion: This meta-analysis suggests that NAC does not have a significant effect in reducing the incidence of AKI. However, there is notable heterogeneity among the included studies that could possibly account for the non-significant effect observed. It is worth noting that only one trial administered NAC high dosages perioperatively, and it is the only included trial to show a significant benefit in reducing the incidence of AKI (OR: 0.30, 95% CI: 0.11–0.81). Further studies on this dosage and duration of administration should be conducted to best elucidate the effect of administering NAC.
Source Title: ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
URI: https://scholarbank.nus.edu.sg/handle/10635/226648
ISSN: 13411098
21861005
DOI: 10.5761/atcs.oa.21-00132
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