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https://doi.org/10.18632/aging.203144
Title: | Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines | Authors: | Gao, Fei Kovalik, Jean-Paul Zhao, Xiaodan Chow, Vivian JM Chew, Hannah Teo, Louis LY Tan, Ru San Leng, Shuang Ewe, See Hooi Tan, Hong Chang Tan, Tsze Yin Lee, Lye Siang Ching, Jianhong Keng, Bryan MH Zhong, Liang Koh, Woon-Puay Koh, Angela S |
Keywords: | Science & Technology Life Sciences & Biomedicine Cell Biology Geriatrics & Gerontology aging diabetes cardiovascular LEFT ATRIAL STRAIN HEART-FAILURE DISEASE ACID PROFILE METABOLOMICS OXIDATION |
Issue Date: | 15-Jun-2021 | Publisher: | IMPACT JOURNALS LLC | Citation: | Gao, Fei, Kovalik, Jean-Paul, Zhao, Xiaodan, Chow, Vivian JM, Chew, Hannah, Teo, Louis LY, Tan, Ru San, Leng, Shuang, Ewe, See Hooi, Tan, Hong Chang, Tan, Tsze Yin, Lee, Lye Siang, Ching, Jianhong, Keng, Bryan MH, Zhong, Liang, Koh, Woon-Puay, Koh, Angela S (2021-06-15). Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines. AGING-US 13 (11) : 14785-14805. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.203144 | Abstract: | Objective: To demonstrate differences in cardiovascular structure and function between diabetic and nondiabetic older adults. To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements. Methods: A community-based cohort of older adults without cardiovascular disease underwent current cardiovascular imaging and metabolomics acyl-carnitines profiling based on current and archived sera obtained fifteen years prior to examination. Results: A total of 933 participants (women 56%, n=521) with a mean age 63±13 years were studied. Old diabetics compared to old non-diabetics had lower myocardial relaxation (0.8±0.2 vs 0.9±0.3, p=0.0039); lower left atrial conduit strain (12±4.3 vs 14±4.1, p=0.045), lower left atrial conduit strain rate (-1.2±0.4 vs -1.3±0.5, p=0.042) and lower ratio of left atrial conduit strain to left atrial booster strain (0.5±0.2 vs 0.7±0.3, p=0.0029). Higher levels of archived short chain acyl-carnitine were associated with present-day impairments in myocardial relaxation (C5:1; OR 1.03, p=0.011), worse left atrial conduit strain function (C5:1; OR 1.03, p=0.037). Increases in hydroxylated acylcarnitines were associated with worse left atrial conduit strain [(C4-OH; OR 1.05, p=0.0017), (C16:2-OH; OR 1.18, p=0.037)]. Current, archived and changes in long chain acyl-carnitines were associated with cardiovascular functions [(C16; OR 1.02, p=0.002), (C20:3; OR 1.01, p=0.014), (C14:3; OR 1.12, p=0.033), (C18:1; OR 1.01, p=0.018), (C18:2; OR 1.01, p=0.028), (C20:4; OR 1.10, p=0.038)] (all p<0.05). Conclusion: Older diabetic adults had significant impairments in left ventricular myocardial relaxation and left atrial strain, compared to older non-diabetic adults. Short chain and long chain, di-carboxyl and hydroxylated acyl-carnitines were associated with these cardiovascular functional differences. | Source Title: | AGING-US | URI: | https://scholarbank.nus.edu.sg/handle/10635/226642 | ISSN: | 19454589 | DOI: | 10.18632/aging.203144 |
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