Please use this identifier to cite or link to this item: https://doi.org/10.18632/aging.203144
Title: Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines
Authors: Gao, Fei 
Kovalik, Jean-Paul 
Zhao, Xiaodan
Chow, Vivian JM
Chew, Hannah
Teo, Louis LY
Tan, Ru San 
Leng, Shuang 
Ewe, See Hooi 
Tan, Hong Chang 
Tan, Tsze Yin 
Lee, Lye Siang 
Ching, Jianhong 
Keng, Bryan MH
Zhong, Liang 
Koh, Woon-Puay 
Koh, Angela S 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
aging
diabetes
cardiovascular
LEFT ATRIAL STRAIN
HEART-FAILURE
DISEASE
ACID
PROFILE
METABOLOMICS
OXIDATION
Issue Date: 15-Jun-2021
Publisher: IMPACT JOURNALS LLC
Citation: Gao, Fei, Kovalik, Jean-Paul, Zhao, Xiaodan, Chow, Vivian JM, Chew, Hannah, Teo, Louis LY, Tan, Ru San, Leng, Shuang, Ewe, See Hooi, Tan, Hong Chang, Tan, Tsze Yin, Lee, Lye Siang, Ching, Jianhong, Keng, Bryan MH, Zhong, Liang, Koh, Woon-Puay, Koh, Angela S (2021-06-15). Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines. AGING-US 13 (11) : 14785-14805. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.203144
Abstract: Objective: To demonstrate differences in cardiovascular structure and function between diabetic and nondiabetic older adults. To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements. Methods: A community-based cohort of older adults without cardiovascular disease underwent current cardiovascular imaging and metabolomics acyl-carnitines profiling based on current and archived sera obtained fifteen years prior to examination. Results: A total of 933 participants (women 56%, n=521) with a mean age 63±13 years were studied. Old diabetics compared to old non-diabetics had lower myocardial relaxation (0.8±0.2 vs 0.9±0.3, p=0.0039); lower left atrial conduit strain (12±4.3 vs 14±4.1, p=0.045), lower left atrial conduit strain rate (-1.2±0.4 vs -1.3±0.5, p=0.042) and lower ratio of left atrial conduit strain to left atrial booster strain (0.5±0.2 vs 0.7±0.3, p=0.0029). Higher levels of archived short chain acyl-carnitine were associated with present-day impairments in myocardial relaxation (C5:1; OR 1.03, p=0.011), worse left atrial conduit strain function (C5:1; OR 1.03, p=0.037). Increases in hydroxylated acylcarnitines were associated with worse left atrial conduit strain [(C4-OH; OR 1.05, p=0.0017), (C16:2-OH; OR 1.18, p=0.037)]. Current, archived and changes in long chain acyl-carnitines were associated with cardiovascular functions [(C16; OR 1.02, p=0.002), (C20:3; OR 1.01, p=0.014), (C14:3; OR 1.12, p=0.033), (C18:1; OR 1.01, p=0.018), (C18:2; OR 1.01, p=0.028), (C20:4; OR 1.10, p=0.038)] (all p<0.05). Conclusion: Older diabetic adults had significant impairments in left ventricular myocardial relaxation and left atrial strain, compared to older non-diabetic adults. Short chain and long chain, di-carboxyl and hydroxylated acyl-carnitines were associated with these cardiovascular functional differences.
Source Title: AGING-US
URI: https://scholarbank.nus.edu.sg/handle/10635/226642
ISSN: 19454589
DOI: 10.18632/aging.203144
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