Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2022.869406
Title: A Review and Meta-Analysis of Influenza Interactome Studies
Authors: Chua, Sonja Courtney Jun Hui 
Cui, Jianzhou 
Engelberg, David 
Lim, Lina Hsiu Kim 
Issue Date: 2022
Publisher: Frontiers Media SA
Citation: Chua, Sonja Courtney Jun Hui, Cui, Jianzhou, Engelberg, David, Lim, Lina Hsiu Kim (2022). A Review and Meta-Analysis of Influenza Interactome Studies. Frontiers in Microbiology 13. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2022.869406
Abstract: Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases. While there are antivirals available against influenza, such as neuraminidase inhibitors and adamantanes, there is growing resistance against these drugs. Thus, there is a need for novel antivirals for resistant influenza strains. Host-directed therapies are a potential strategy for influenza as host processes are conserved and are less prone mutations as compared to virus-directed therapies. A literature search was performed for papers that performed viral–host interaction screens and the Reactome pathway database was used for the bioinformatics analysis. A total of 15 studies were curated and 1717 common interactors were uncovered among all these studies. KEGG analysis, Enrichr analysis, STRING interaction analysis was performed on these interactors. Therefore, we have identified novel host pathways that can be targeted for host-directed therapy against influenza in our review.
Source Title: Frontiers in Microbiology
URI: https://scholarbank.nus.edu.sg/handle/10635/224156
ISSN: 1664302X
DOI: 10.3389/fmicb.2022.869406
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