Please use this identifier to cite or link to this item: https://doi.org/10.3402/pba.v2i0.17391
Title: Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells.
Authors: Fatemie, Sy
Goh, Jorming 
Pettan-Brewer, Christina
Ladiges, Warren
Keywords: endothelial cells
immunohistochemistry of mouse breast cancer
mitochondrial catalase
reactive oxygen species
tumor associated macrophages
Issue Date: 2012
Publisher: Informa UK Limited
Citation: Fatemie, Sy, Goh, Jorming, Pettan-Brewer, Christina, Ladiges, Warren (2012). Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells.. Pathobiol Aging Age Relat Dis 2 (1) : 17391-17391. ScholarBank@NUS Repository. https://doi.org/10.3402/pba.v2i0.17391
Abstract: We show by immunohistochemical labeling that prominent cell types in the tumor microenvironment of PyMT transgenic mice are tumor-associated macrophages (TAMs) and endothelial cells, and that both populations are decreased in the presence of mitochondrial targeted catalase (mCAT). This observation suggests that mitochondrial ROS can drive tumor invasiveness in conjunction with the presence of TAMs and increased angiogenesis. Since primary PyMT tumor cells expressing mCAT undergo increased apoptosis, mitochondrial antioxidants might be attractive anti-tumor agents.
Source Title: Pathobiol Aging Age Relat Dis
URI: https://scholarbank.nus.edu.sg/handle/10635/219462
ISSN: 2001-0001
DOI: 10.3402/pba.v2i0.17391
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