Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/219453
Title: Exercise training and immune crosstalk in breast cancer microenvironment: exploring the paradigms of exercise-induced immune modulation and exercise-induced myokines
Authors: Goh, Jorming 
Niksirat, Negin
Campbell, Kristin L
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Medicine, Research & Experimental
Research & Experimental Medicine
Exercise
breast cancer
immune
myokines
translational
immunotherapy
TUMOR-ASSOCIATED MACROPHAGES
LYMPHOCYTES PREDICT RESPONSE
RANDOMIZED CONTROLLED-TRIAL
C-REACTIVE PROTEIN
QUALITY-OF-LIFE
PHYSICAL-ACTIVITY
SKELETAL-MUSCLE
INTENSITY EXERCISE
BIOMARKERS
MONOCYTES
Issue Date: 1-Jan-2014
Publisher: E-CENTURY PUBLISHING CORP
Citation: Goh, Jorming, Niksirat, Negin, Campbell, Kristin L (2014-01-01). Exercise training and immune crosstalk in breast cancer microenvironment: exploring the paradigms of exercise-induced immune modulation and exercise-induced myokines. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 6 (5) : 422-U215. ScholarBank@NUS Repository.
Abstract: Observational research suggests that exercise may reduce the risk of breast cancer and improve survival. One proposed mechanism for the protective effect of aerobic exercise related to cancer risk and outcomes, but has not been examined definitively, is the immune response to aerobic exercise. Two prevailing paradigms are proposed. The first considers the host immune response as modifiable by aerobic exercise training. This exercise-modulated immune-tumor crosstalk in the mammary microenvironment may alter the balance between tumor initiation and progression versus tumor suppression. The second paradigm considers the beneficial role of exercise-induced, skeletal muscle-derived cytokines, termed “myokines”. These myokines exert endocrine-like effects on multiple organs, including the mammary glands. In this systematic review, we i) define the role of macrophages and T-cells in breast cancer initiation and progression; ii) address the two paradigms that support exercise-induced immunomodulation; iii) systematically assessed the literature for exercise intervention that assessed biomarkers relevant to both paradigms in human intervention trials of aerobic exercise training, in healthy women and women with breast cancer; iv) incorporated pre-clinical animal studies and non-RCTs for background discussion of putative mechanisms, through which aerobic exercise training modulates the immunological crosstalk, or the myokine-tumor interaction in the tumor microenvironment; and v) speculated on the potential biomarkers and mechanisms that define an exercise-induced, anti-tumor “signature”, with a view toward developing relevant biomarkers for future aerobic exercise intervention trials.
Source Title: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/219453
ISSN: 1943-8141
1943-8141
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Goh 2014 - Exercise training and immune crosstalk in breast cancer microenvironment.pdf542.14 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

46
checked on Sep 29, 2022

Download(s)

1
checked on Sep 29, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.