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Title: Voluntary Wheel Running in Mice
Authors: Goh, J 
Ladiges, W
Keywords: exercise training
exercised-induced health benefits
mouse fitness testing
running endurance
voluntary wheel running
Motor Activity
Physical Conditioning, Animal
Issue Date: 2-Dec-2015
Publisher: Wiley
Citation: Goh, J, Ladiges, W (2015-12-02). Voluntary Wheel Running in Mice. Current protocols in mouse biology 5 (4) : 283-290. ScholarBank@NUS Repository.
Abstract: Voluntary wheel running in the mouse is used to assess physical performance and endurance and to model exercise training as a way to enhance health. Wheel running is a voluntary activity in contrast to other experimental exercise models in mice, which rely on aversive stimuli to force active movement. This protocol consists of allowing mice to run freely on the open surface of a slanted, plastic saucer-shaped wheel placed inside a standard mouse cage. Rotations are electronically transmitted to a USB hub so that frequency and rate of running can be captured via a software program for data storage and analysis for variable time periods. Mice are individually housed so that accurate recordings can be made for each animal. Factors such as mouse strain, gender, age, and individual motivation, which affect running activity, must be considered in the design of experiments using voluntary wheel running.
Source Title: Current protocols in mouse biology
ISSN: 2161-2617
DOI: 10.1002/9780470942390.mo140295
Appears in Collections:Staff Publications

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