Please use this identifier to cite or link to this item: https://doi.org/10.3390/antiox7120196
Title: Monocyte Subsets in Atherosclerosis and Modification with Exercise in Humans
Authors: Aw, Ning Hong
Canetti, Elisa
Suzuki, Katsuhiko
Goh, Jorming 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Food Science & Technology
Pharmacology & Pharmacy
monocytes
exercise training
atherosclerosis
inflammation
NECROSIS-FACTOR-ALPHA
RECEPTOR EXPRESSION
ENDOTHELIAL FUNCTION
MONONUCLEAR-CELLS
PHYSICAL-ACTIVITY
BLOOD MONOCYTES
DENDRITIC CELLS
TNF-ALPHA
INFLAMMATION
HETEROGENEITY
Issue Date: 1-Dec-2018
Publisher: MDPI
Citation: Aw, Ning Hong, Canetti, Elisa, Suzuki, Katsuhiko, Goh, Jorming (2018-12-01). Monocyte Subsets in Atherosclerosis and Modification with Exercise in Humans. ANTIOXIDANTS 7 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/antiox7120196
Abstract: Atherosclerosis is a progressive pathological remodeling of the arteries and one of its hallmarks is the presence of chronic inflammation. Notably, there is an increased proportion and activation state of specific monocyte subsets in systemic blood circulation. Monocyte subsets have distinct contributions to the formation, progression, and destabilization of the atherosclerotic plaque. Strong clinical and epidemiological studies show that regular aerobic exercise mitigates the progression of cardiovascular disease. In fact, aerobic fitness is a powerful predictor of cardiovascular mortality in adults, independent of traditional risk factors such as hypertension and hyperlipidemia. Acute bouts and chronic exercise training modulate monocyte behavior, ranging from their recruitment from the bone marrow or marginal pool, to tissue margination and functional changes in cytokine and chemokine production. Such modulation could reflect a potential mechanism for the cardio-protective effect of exercise on atherosclerosis. This review summarizes the current knowledge of monocyte subsets and highlights what is known about their responses to exercise.
Source Title: ANTIOXIDANTS
URI: https://scholarbank.nus.edu.sg/handle/10635/219444
ISSN: 2076-3921
DOI: 10.3390/antiox7120196
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