Please use this identifier to cite or link to this item: https://doi.org/10.1080/20010001.2019.1647746
Title: Rapamycin increases breast tumor burden in young wheel-running mice.
Authors: Wang, Juan
Truong, Thomas
Ladiges, Warren
Goh, Jorming 
Keywords: Rapamycin
age-related disease
aging intervention
breast cancer
mouse model
wheel running
Issue Date: 2019
Publisher: Informa UK Limited
Citation: Wang, Juan, Truong, Thomas, Ladiges, Warren, Goh, Jorming (2019). Rapamycin increases breast tumor burden in young wheel-running mice.. Pathobiol Aging Age Relat Dis 9 (1) : 1647746-. ScholarBank@NUS Repository. https://doi.org/10.1080/20010001.2019.1647746
Abstract: Rapamycin is an immunosuppressive and anti-cancer drug recently shown to enhance healthy aging in animal models. Regular physical exercise is associated with healthy aging and reduced risk of age-related diseases, such as cancer. In order to test the combined effect of these approaches, mice with 4T1 breast cancer were fed rapamycin at 14 ppm and allowed access to voluntary running wheels. After 17 days of treatment, mice fed the rapamycin diet that ran showed a significant increase in tumor burden compared with mice that did not run (P = 0.017). Not only does this have implications for young breast cancer patients, but suggests that combining rapamycin and exercise as an anti-aging strategy at a young age might be contraindicated.
Source Title: Pathobiol Aging Age Relat Dis
URI: https://scholarbank.nus.edu.sg/handle/10635/219442
ISSN: 2001-0001
DOI: 10.1080/20010001.2019.1647746
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