Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12967-021-02737-1
Title: Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia
Authors: Harper, Colin
Gopalan, Venkatesh
Goh, Jorming 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
Skeletal muscle
Mitochondria
Aging
Exercise
DNA-DELETION MUTATIONS
MAGNETIC-RESONANCE-SPECTROSCOPY
ANTIOXIDANT ENZYME-ACTIVITY
OXIDATIVE CAPACITY
FIBER-TYPE
GENE-EXPRESSION
NEUROMUSCULAR ADAPTATIONS
CONCURRENT STRENGTH
ENDURANCE EXERCISE
RESISTANCE
Issue Date: 16-Feb-2021
Publisher: BMC
Citation: Harper, Colin, Gopalan, Venkatesh, Goh, Jorming (2021-02-16). Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia. JOURNAL OF TRANSLATIONAL MEDICINE 19 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12967-021-02737-1
Abstract: Skeletal muscle aging is associated with a decline in motor function and loss of muscle mass- a condition known as sarcopenia. The underlying mechanisms that drive this pathology are associated with a failure in energy generation in skeletal muscle, either from age-related decline in mitochondrial function, or from disuse. To an extent, lifelong exercise is efficacious in preserving the energetic properties of skeletal muscle and thus may delay the onset of sarcopenia. This review discusses the cellular and molecular changes in skeletal muscle mitochondria during the aging process and how different exercise modalities work to reverse these changes. A key factor that will be described is the efficiency of mitochondrial coupling—ATP production relative to O2 uptake in myocytes and how that efficiency is a main driver for age-associated decline in skeletal muscle function. With that, we postulate the most effective exercise modality and protocol for reversing the molecular hallmarks of skeletal muscle aging and staving off sarcopenia. Two other concepts pertinent to mitochondrial efficiency in exercise-trained skeletal muscle will be integrated in this review, including- mitophagy, the removal of dysfunctional mitochondrial via autophagy, as well as the implications of muscle fiber type changes with sarcopenia on mitochondrial function.
Source Title: JOURNAL OF TRANSLATIONAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/219439
ISSN: 1479-5876
1479-5876
DOI: 10.1186/s12967-021-02737-1
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Exercise rescues mitochondrial coupling in aged skeletal muscle a comparison of different modalities in preventing sarcopeni.pdf1.27 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

9
checked on Oct 1, 2022

Page view(s)

49
checked on Oct 6, 2022

Download(s)

1
checked on Oct 6, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.