Please use this identifier to cite or link to this item: https://doi.org/10.1080/21645515.2016.1228500
Title: Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks Implications for coronavirus vaccine development
Authors: Ng, Oi-Wing
Tan, Yee-Joo 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Immunology
Bats
Emerging and re-emerging virus
Severe acute respiratory syndrome coronavirus
SARS-like coronavirus
Zoonotic virus
ACUTE RESPIRATORY SYNDROME
EBOLA-VIRUS
MERS-COV
EVOLUTION
INHIBIT
TARGET
Issue Date: 1-Jan-2017
Publisher: TAYLOR & FRANCIS INC
Citation: Ng, Oi-Wing, Tan, Yee-Joo (2017-01-01). Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks Implications for coronavirus vaccine development. HUMAN VACCINES & IMMUNOTHERAPEUTICS 13 (1) : 186-189. ScholarBank@NUS Repository. https://doi.org/10.1080/21645515.2016.1228500
Abstract: The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.
Source Title: HUMAN VACCINES & IMMUNOTHERAPEUTICS
URI: https://scholarbank.nus.edu.sg/handle/10635/219377
ISSN: 21645515
2164554X
DOI: 10.1080/21645515.2016.1228500
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