Please use this identifier to cite or link to this item: https://doi.org/10.1007/s12250-019-00116-1
Title: The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein, Induce Apoptosis in HEp-2 and Vero Cells
Authors: Xu, Yishi
Victorio, Carla Bianca Luena 
Meng, Tao
Jia, Qiang
Tan, Yee-Joo 
Chua, Kaw Bing
Keywords: Science & Technology
Life Sciences & Biomedicine
Virology
Saffold virus (SAFV)
Apoptosis
Viral proteins
MURINE ENCEPHALOMYELITIS VIRUS
ENDOPLASMIC-RETICULUM
LEADER PROTEIN
INFECTION
MEMBRANE
MACROPHAGES
ACTIVATION
CLEAVAGE
PERMEABILIZATION
DIFFERENTIATION
Issue Date: 1-Jun-2019
Publisher: SPRINGER
Citation: Xu, Yishi, Victorio, Carla Bianca Luena, Meng, Tao, Jia, Qiang, Tan, Yee-Joo, Chua, Kaw Bing (2019-06-01). The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein, Induce Apoptosis in HEp-2 and Vero Cells. VIROLOGICA SINICA 34 (3) : 262-269. ScholarBank@NUS Repository. https://doi.org/10.1007/s12250-019-00116-1
Abstract: Our previous work has shown that Saffold virus (SAFV) induced several rodent and primate cell lines to undergo apoptosis (Xu et al. in Emerg Microb Infect 3:1–8, 2014), but the essential viral proteins of SAFV involved in apoptotic activity lack study. In this study, we individually transfected the viral proteins of SAFV into HEp-2 and Vero cells to assess their ability to induce apoptosis, and found that the 2B and 3C proteins are proapoptotic. Further investigation indicated the transmembrane domain of the 2B protein is essential for the apoptotic activity and tetramer formation of the 2B protein. Our research provides clues for the possible mechanisms of apoptosis induced by SAFV in different cell lines. It also opens up new directions to study viral proteins (the 2B, 3C protein), and sets the stage for future exploration of any possible link between SAFV, inclusive of its related uncultivable genotypes, and multiple sclerosis.
Source Title: VIROLOGICA SINICA
URI: https://scholarbank.nus.edu.sg/handle/10635/219374
ISSN: 16740769
1995820X
DOI: 10.1007/s12250-019-00116-1
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