Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers14010020
Title: Autophagy and ncrnas: Dangerous liaisons in the crosstalk between the tumor and its microenvironment
Authors: Eng, GWL 
Zheng, Y
Yap, DWT
Teo, AYT
Cheong, JK 
Issue Date: 1-Jan-2022
Publisher: MDPI AG
Citation: Eng, GWL, Zheng, Y, Yap, DWT, Teo, AYT, Cheong, JK (2022-01-01). Autophagy and ncrnas: Dangerous liaisons in the crosstalk between the tumor and its microenvironment. Cancers 14 (1) : 20-20. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers14010020
Abstract: Autophagy is a fundamental cellular homeostasis mechanism known to play multifaceted roles in the natural history of cancers over time. It has recently been shown that autophagy also mediates the crosstalk between the tumor and its microenvironment by promoting the export of molecular payloads such as non-coding RNA (ncRNAs) via LC3-dependent Extracellular Vesicle loading and secretion (LDELS). In turn, the dynamic exchange of exosomal ncRNAs regulate au-tophagic responses in the recipient cells within the tumor microenvironment (TME), for both tumor and stromal cells. Autophagy-dependent phenotypic changes in the recipient cells further enhance tumor growth and metastasis, through diverse biological processes, including nutrient supplemen-tation, immune evasion, angiogenesis, and therapeutic resistance. In this review, we discuss how the feedforward autophagy-ncRNA axis orchestrates vital communications between various cell types within the TME ecosystem to promote cancer progression.
Source Title: Cancers
URI: https://scholarbank.nus.edu.sg/handle/10635/219300
ISSN: 20726694
DOI: 10.3390/cancers14010020
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