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Title: Advances in quantifying circulatory microRNA for early disease detection
Authors: Cheong, JK 
Tang, YC 
Zhou, L 
Cheng, H
Too, HP 
Issue Date: 1-Apr-2022
Publisher: Elsevier BV
Citation: Cheong, JK, Tang, YC, Zhou, L, Cheng, H, Too, HP (2022-04-01). Advances in quantifying circulatory microRNA for early disease detection. Current Opinion in Biotechnology 74 : 256-262. ScholarBank@NUS Repository.
Abstract: Precision preventive healthcare aims to improve patient health by integrating preventive measures with early disease detection for timely intervention with precision medicine. Key to the delivery of preventive healthcare is the clinical adoption of novel assays that enable early disease detection. Such assays, typically based on biomarkers such as microRNAs (miRNAs) from liquid biopsy or excreta, are entering clinical practice after years of clinical development and validation. In this review, we discuss the clinical utility and validation of miRNA-based molecular diagnostics for early disease detection through large-cohort studies and key considerations for developing multi-analyte clinical assays. We also highlight recent advances in the ongoing development of integrated PCR-free miRNA detection systems for point-of-care testing.
Source Title: Current Opinion in Biotechnology
ISSN: 09581669
DOI: 10.1016/j.copbio.2021.12.007
Appears in Collections:Staff Publications

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