Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0306-4522(02)00989-2
Title: Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors?
Authors: Ang, ET 
Wong, PTH 
Moochhala, S 
Ng, YK
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
treadmill running
NGF
p75
ChAT
stroke
NERVE GROWTH-FACTOR
FOCAL CEREBRAL-ISCHEMIA
REDUCES INFARCT SIZE
MESSENGER-RNA EXPRESSION
CHOLINERGIC NEURONS
PHYSICAL-ACTIVITY
BASAL FOREBRAIN
RAT-BRAIN
HIPPOCAMPAL-NEURONS
LOCOMOTOR-ACTIVITY
Issue Date: 1-Jan-2003
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: Ang, ET, Wong, PTH, Moochhala, S, Ng, YK (2003-01-01). Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors?. NEUROSCIENCE 118 (2) : 335-345. ScholarBank@NUS Repository. https://doi.org/10.1016/S0306-4522(02)00989-2
Abstract: The possible neuroprotective effect of physical exercise was investigated in rats after middle cerebral artery occlusion (MCAO), a focal stroke model. It was found that physical exercise in the form of a 12-week treadmill running programme reduced the volume of infarction caused by MCAO. At the molecular level, reverse transcription polymerase chain reaction revealed that the runner had increased gene expression for nerve growth factor (NGF) over the nonrunner with or without MCAO. Expression of the NGF receptors, p75, was increased only in the absence of MCAO. In addition, runners showed a significantly higher number of cholinergic neurons, which constitutively expressed p75, in the horizontal diagonal band of Broca. The present findings suggest that neuroprotection after physical exercise may be a result of an increase in an endogenous neurotrophic factor nerve growth factor and the proliferation of its receptive cholinergic neurons. © 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
Source Title: NEUROSCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/219295
ISSN: 03064522
18737544
DOI: 10.1016/S0306-4522(02)00989-2
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