Please use this identifier to cite or link to this item: https://doi.org/10.1089/ars.2019.7896
Title: Biological Effects of Morpholin-4-Ium 4 Methoxyphenyl (Morpholino) Phosphinodithioate and Other Phosphorothioate-Based Hydrogen Sulfide Donors
Authors: Nin, DS 
Idres, SB 
Song, ZJ
Moore, PK 
Deng, LW 
Keywords: GYY4137
H2S
hydrogen sulfide
slow-releasing H2S donor
Animals
Humans
Hydrogen Sulfide
Molecular Structure
Morpholines
Organothiophosphorus Compounds
Phosphorothioate Oligonucleotides
Structure-Activity Relationship
Issue Date: 10-Jan-2020
Publisher: Mary Ann Liebert Inc
Citation: Nin, DS, Idres, SB, Song, ZJ, Moore, PK, Deng, LW (2020-01-10). Biological Effects of Morpholin-4-Ium 4 Methoxyphenyl (Morpholino) Phosphinodithioate and Other Phosphorothioate-Based Hydrogen Sulfide Donors. Antioxidants and Redox Signaling 32 (2) : 145-158. ScholarBank@NUS Repository. https://doi.org/10.1089/ars.2019.7896
Abstract: Significance: Hydrogen sulfide (H2S) is regarded as the third gasotransmitter along with nitric oxide and carbon monoxide. Extensive studies have demonstrated a variety of biological roles for H2S in neurophysiology, cardiovascular disease, endocrine regulation, and other physiological and pathological processes. Recent Advances: Novel H2S donors have proved useful in understanding the biological functions of H2S, with morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) being one of the most common pharmacological tools used. One advantage of GYY4137 over sulfide salts is its ability to release H2S in a slow and sustained manner akin to endogenous H2S production, rather than the delivery of H2S as a single concentrated burst. Critical Issues: Here, we summarize recent progress made in the characterization of the biological activities and pharmacological effects of GYY4137 in a range of in vitro and in vivo systems. Recent developments in the structural modification of GYY4137 to generate new compounds and their biological effects are also discussed. Future Directions: Slow-releasing H2S donor, GYY4137, and other phosphorothioate-based H2S donors are potent tools to study the biological functions of H2S. Despite recent progress, more work needs to be performed on these new compounds to unravel the mechanisms behind H2S release and pace of its discharge, as well as to define the effects of by-products of donors after H2S liberation. This will not only lead to better in-depth understanding of the biological effects of H2S but will also shed light on the future development of a new class of therapeutic agents with potential to treat a wide range of human diseases.
Source Title: Antioxidants and Redox Signaling
URI: https://scholarbank.nus.edu.sg/handle/10635/219036
ISSN: 1523-0864
1557-7716
DOI: 10.1089/ars.2019.7896
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