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https://doi.org/10.1212/WNL.0000000000008612
Title: | Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups | Authors: | Lo, Jessica W Crawford, John D Desmond, David W Godefroy, Olivier Jokinen, Hanna Mahinrad, Simin Bae, Hee-Joon Lim, Jae-Sung Kohler, Sebastian Douven, Elles Staals, Julie Chen, Christopher Xu, Xin Chong, Eddie J Akinyemi, Rufus O Kalaria, Rajesh N Ogunniyi, Adesola Barbay, Melanie Roussel, Martine Lee, Byung-Chul Srikanth, Velandai K Moran, Christopher Kandiah, Nagaendran Chander, Russell J Sabayan, Behnam Jukema, J Wouter Melkas, Susanna Erkinjuntti, Timo Brodaty, Henry Bordet, Regis Bombois, Stephanie Henon, Hilde Lipnicki, Darren M Kochan, Nicole A Sachdev, Perminder S Brodtmann, Amy Klimkowicz-Mrowiec, Aleksandra Dichgans, Martin Hoffmann, Michael Linden, Thomas Wardlaw, Joanna Cordonnier, Charlotte Mok, Vincent |
Keywords: | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences & Neurology INDIVIDUAL PARTICIPANT DATA DEMENTIA STROKE METAANALYSIS HYPERTENSION STATEMENT |
Issue Date: | 10-Dec-2019 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Citation: | Lo, Jessica W, Crawford, John D, Desmond, David W, Godefroy, Olivier, Jokinen, Hanna, Mahinrad, Simin, Bae, Hee-Joon, Lim, Jae-Sung, Kohler, Sebastian, Douven, Elles, Staals, Julie, Chen, Christopher, Xu, Xin, Chong, Eddie J, Akinyemi, Rufus O, Kalaria, Rajesh N, Ogunniyi, Adesola, Barbay, Melanie, Roussel, Martine, Lee, Byung-Chul, Srikanth, Velandai K, Moran, Christopher, Kandiah, Nagaendran, Chander, Russell J, Sabayan, Behnam, Jukema, J Wouter, Melkas, Susanna, Erkinjuntti, Timo, Brodaty, Henry, Bordet, Regis, Bombois, Stephanie, Henon, Hilde, Lipnicki, Darren M, Kochan, Nicole A, Sachdev, Perminder S, Brodtmann, Amy, Klimkowicz-Mrowiec, Aleksandra, Dichgans, Martin, Hoffmann, Michael, Linden, Thomas, Wardlaw, Joanna, Cordonnier, Charlotte, Mok, Vincent (2019-12-10). Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. NEUROLOGY 93 (24) : E2257-E2271. ScholarBank@NUS Repository. https://doi.org/10.1212/WNL.0000000000008612 | Abstract: | ObjectiveTo address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium.MethodsWe harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis.ResultsIn a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition.ConclusionsThis study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies. | Source Title: | NEUROLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/218824 | ISSN: | 0028-3878 1526-632X |
DOI: | 10.1212/WNL.0000000000008612 |
Appears in Collections: | Staff Publications Elements |
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