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Title: Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups
Authors: Lo, Jessica W
Crawford, John D
Desmond, David W
Godefroy, Olivier
Jokinen, Hanna
Mahinrad, Simin
Bae, Hee-Joon
Lim, Jae-Sung
Kohler, Sebastian
Douven, Elles
Staals, Julie
Chen, Christopher 
Xu, Xin
Chong, Eddie J
Akinyemi, Rufus O
Kalaria, Rajesh N
Ogunniyi, Adesola
Barbay, Melanie
Roussel, Martine
Lee, Byung-Chul
Srikanth, Velandai K
Moran, Christopher
Kandiah, Nagaendran 
Chander, Russell J
Sabayan, Behnam
Jukema, J Wouter
Melkas, Susanna
Erkinjuntti, Timo
Brodaty, Henry
Bordet, Regis
Bombois, Stephanie
Henon, Hilde
Lipnicki, Darren M
Kochan, Nicole A
Sachdev, Perminder S
Brodtmann, Amy
Klimkowicz-Mrowiec, Aleksandra
Dichgans, Martin
Hoffmann, Michael
Linden, Thomas
Wardlaw, Joanna
Cordonnier, Charlotte
Mok, Vincent
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Issue Date: 10-Dec-2019
Citation: Lo, Jessica W, Crawford, John D, Desmond, David W, Godefroy, Olivier, Jokinen, Hanna, Mahinrad, Simin, Bae, Hee-Joon, Lim, Jae-Sung, Kohler, Sebastian, Douven, Elles, Staals, Julie, Chen, Christopher, Xu, Xin, Chong, Eddie J, Akinyemi, Rufus O, Kalaria, Rajesh N, Ogunniyi, Adesola, Barbay, Melanie, Roussel, Martine, Lee, Byung-Chul, Srikanth, Velandai K, Moran, Christopher, Kandiah, Nagaendran, Chander, Russell J, Sabayan, Behnam, Jukema, J Wouter, Melkas, Susanna, Erkinjuntti, Timo, Brodaty, Henry, Bordet, Regis, Bombois, Stephanie, Henon, Hilde, Lipnicki, Darren M, Kochan, Nicole A, Sachdev, Perminder S, Brodtmann, Amy, Klimkowicz-Mrowiec, Aleksandra, Dichgans, Martin, Hoffmann, Michael, Linden, Thomas, Wardlaw, Joanna, Cordonnier, Charlotte, Mok, Vincent (2019-12-10). Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. NEUROLOGY 93 (24) : E2257-E2271. ScholarBank@NUS Repository.
Abstract: ObjectiveTo address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium.MethodsWe harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis.ResultsIn a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition.ConclusionsThis study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.
Source Title: NEUROLOGY
ISSN: 0028-3878
DOI: 10.1212/WNL.0000000000008612
Appears in Collections:Staff Publications

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