Please use this identifier to cite or link to this item: https://doi.org/10.1111/cns.13536
Title: Strategies for the use of Ginkgo biloba extract, EGb 761(R), in the treatment and management of mild cognitive impairment in Asia: Expert consensus
Authors: Kandiah, Nagaendran 
Chan, Yee Fai
Chen, Christopher 
Dasig, Darwin
Dominguez, Jacqueline
Han, Seol-Heui
Jia, Jianping
Kim, SangYun
Limpawattana, Panita
Ng, Li-Ling
Dinh, Toan Nguyen
Ong, Paulus Anam
Raya-Ampil, Encarnita
Saedon, Nor'izzati
Senanarong, Vorapun
Setiati, Siti
Singh, Harjot
Suthisisang, Chuthamanee
Tong, Mai Trang
Turana, Yuda
Venketasubramanian, Narayanaswamy 
Yong, Fee Mann
Youn, Yong Chul
Ihl, Ralf
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Pharmacology & Pharmacy
Neurosciences & Neurology
cerebrovascular disease
dementia
EGb 761(&#174)
Ginkgo biloba
mild cognitive impairment
neuropsychiatric symptoms
ALZHEIMERS-DISEASE
NEUROPSYCHIATRIC SYMPTOMS
DOUBLE-BLIND
CEREBROVASCULAR-DISEASE
PSYCHOLOGICAL SYMPTOMS
PREDICTS PROGRESSION
DIAGNOSTIC-CRITERIA
MEMORY IMPAIRMENT
RANDOMIZED-TRIAL
BLEEDING-TIME
Issue Date: 22-Dec-2020
Publisher: WILEY
Citation: Kandiah, Nagaendran, Chan, Yee Fai, Chen, Christopher, Dasig, Darwin, Dominguez, Jacqueline, Han, Seol-Heui, Jia, Jianping, Kim, SangYun, Limpawattana, Panita, Ng, Li-Ling, Dinh, Toan Nguyen, Ong, Paulus Anam, Raya-Ampil, Encarnita, Saedon, Nor'izzati, Senanarong, Vorapun, Setiati, Siti, Singh, Harjot, Suthisisang, Chuthamanee, Tong, Mai Trang, Turana, Yuda, Venketasubramanian, Narayanaswamy, Yong, Fee Mann, Youn, Yong Chul, Ihl, Ralf (2020-12-22). Strategies for the use of Ginkgo biloba extract, EGb 761(R), in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS NEUROSCIENCE & THERAPEUTICS 27 (2) : 149-162. ScholarBank@NUS Repository. https://doi.org/10.1111/cns.13536
Abstract: Background: Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable proportion display neuropsychiatric symptoms (NPS), also a known risk factor for dementia. Cerebrovascular disease (CVD) is thought to be an underdiagnosed contributor to MCI/dementia. The Ginkgo biloba extract, EGb 761®, is increasingly being used for the symptomatic treatment of cognitive disorders with/without CVD, due to its known neuroprotective effects and cerebrovascular benefits. Aims: To present consensus opinion from the ASian Clinical Expert group on Neurocognitive Disorders (ASCEND) regarding the role of EGb 761® in MCI. Materials & Methods: The ASCEND Group reconvened in September 2019 to present and critically assess the current evidence on the general management of MCI, including the efficacy and safety of EGb 761® as a treatment option. Results: EGb 761® has demonstrated symptomatic improvement in at least four randomized trials, in terms of cognitive performance, memory, recall and recognition, attention and concentration, anxiety, and NPS. There is also evidence that EGb 761® may help delay progression from MCI to dementia in some individuals. Discussion: EGb 761® is currently recommended in multiple guidelines for the symptomatic treatment of MCI. Due to its beneficial effects on cerebrovascular blood flow, it is reasonable to expect that EGb 761® may benefit MCI patients with underlying CVD. Conclusion: As an expert group, we suggest it is clinically appropriate to incorporate EGb 761® as part of the multidomain intervention for MCI.
Source Title: CNS NEUROSCIENCE & THERAPEUTICS
URI: https://scholarbank.nus.edu.sg/handle/10635/218818
ISSN: 1755-5930
1755-5949
DOI: 10.1111/cns.13536
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Strategies for the use of Ginkgo biloba extract, EGb 761sup®sup , in the treatment and management of mild cognitive impairme.pdf1.11 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.